Evidence map›Paper›PMID 41917074›Full record

ArticleNPJ Parkinson's disease2026

In-vivo histology of Parkinson's disease using quantitative multiparametric mapping.

Marta M Pokotylo, Martin Göttlich, Laura Schmidt, Helena Sophia Weingarten, Lydia Dirksen, Lea Albrecht, Norman Griebner, Jan Uter, Julia Henkel, Norbert Brüggemann and 1 more

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marta M PokotyloSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Martin GöttlichCenter for Brain, Behaviour, and Metabolism, University of Lübeck, Lübeck, Germany.
Laura SchmidtSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Helena Sophia WeingartenSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Lydia DirksenCenter for Brain, Behaviour, and Metabolism, University of Lübeck, Lübeck, Germany.
Lea AlbrechtSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Norman GriebnerSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Jan UterSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Julia HenkelSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Norbert BrüggemannSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. norbert.brueggemann@uni-luebeck.de.
Jannik PrasuhnSection of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Funding

Else-Kröner-Fresenius Stiftung 2023_EKEA.168
6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease caused by the loss of dopaminergic neurons; however, growing evidence indicates the widespread involvement of cortical regions underlying motor and non-motor symptoms. In this study, we evaluated multiparametric mapping (MPM) as a non-invasive imaging technique for the detection of microstructural brain alterations in PD. We assessed 31 patients with idiopathic PD (PwPD) and 68 healthy controls (HCs) utilizing MPM-derived longitudinal relaxation rate (R1), effective transverse relaxation rate (R2*), proton density, and magnetic transfer saturation (MTsat). We performed a whole-brain voxel-based quantification (VBQ) and multiple linear regression analysis to assess group differences and associations with the clinical phenotype. Lower MTsat within the left superior frontal gyrus (SFG) predicted motor symptom severity in PwPD, while higher R2* values in the right SFG were associated with higher levodopa-equivalent daily dose. Higher R2* values in the posterior cingulate gyrus and lower proton density in the left superior parietal lobule were associated with a stronger cognitive impairment in PwPD. Additionally, numerous clusters presented with group differences across multiple MPM modalities, including the supplementary motor area and cingulate cortex. Overall, we successfully replicated previously documented cortical microstructural changes in PwPD, presenting MPM as a sensitive tool for the detection of disease-specific alterations. This study further underscores the utility of MPM for monitoring disease progression through biologically informed measures, opening avenues for further research.

Identifiers

PMID41917074
PMCPMC13046743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.