Evidence map›Paper›PMID 41916978›Full record

ArticleNature communications2026

Induction and regulation of reversible suspended animation in C. elegans.

Junqiang Liu, Bingying Wang, Jonathan Leon Catrow, Quentinn Pearce, Zhijian Ji, Supeng Winnie Yang, Akash Balakrishnan, James E Cox, Dengke K Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Junqiang LiuCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2953-487X
Bingying WangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Jonathan Leon CatrowMetabolomics Core Research Facility, Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Quentinn PearceMetabolomics Core Research Facility, Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Zhijian JiCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0005-6314-0961
Supeng Winnie YangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Akash BalakrishnanCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
James E CoxMetabolomics Core Research Facility, Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-5977-2350
Dengke K MaCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA. Dengke.Ma@ucsf.edu.ORCID http://orcid.org/0000-0002-5619-7485

Funding

Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
NIGMS NIH HHS R35 GM139618Sandler Foundation UCSF-PBBR-NFRU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM139618
6 · The paper itself

Abstract

Suspended animation, a state of profound metabolic, behavioral and developmental quiescence, is a remarkable yet poorly understood stress resilience strategy in animals. Here, we describe a previously uncharacterized form of suspended animation inducible by high-population density in isosmotic liquids in C. elegans throughout larval development and adulthood. Transcriptomic, metabolomic, and live-cell activity reporter imaging analyses reveal striking molecular and cellular landscape changes caused by such liquid-induced suspended animation (LISA), including remodeling of gene expression programs, energy metabolites, lysosomal and mitochondrial morphology. Genetic screens identify mutants with altered stress responses and survival against LISA. While key endo-lysosomal regulators promote survival during LISA, organelle remodeling and a neuronal axis via downstream neuropeptide and cAMP/PKA signaling orchestrate behavioral awakening from LISA. Our findings define a facile paradigm for reversible SA, providing a powerful model system to uncover key molecular and cellular mechanisms governing an extreme case of reversible life arrest and dormancy.

Indexed as

Caenorhabditis elegansAnimalsCaenorhabditis elegans ProteinsCyclic AMPCyclic AMP-Dependent Protein KinasesLarvaLysosomesMitochondriaMutationNeuropeptidesSignal TransductionStress, PhysiologicalCaenorhabditis elegans ProteinsCyclic AMPCyclic AMP-Dependent Protein KinasesNeuropeptides

Identifiers

PMID41916978
PMCPMC13199508

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.