Evidence map›Paper›PMID 41916826›Full record

ArticleTrends in cell biology2026

Whi3key old fashioned: a condensate cocktail for cell fate decisions.

Cameron O Schmitz, Ankur Jain

Abstract read
In one paragraph

Article in Trends in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cameron O SchmitzWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA.
Ankur JainWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA. Electronic address: ajain@wi.mit.edu.

Funding

Elucidating the molecular and cellular functions of polyaminesR35GM151111 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Ankur Jain · 2023 to 2026
$1.9M
NIGMS NIH HHS R35 GM151111
6 · The paper itself

Abstract

How do single cells weigh conflicting internal and external signals to arrive at unambiguous fate decisions? Peskett et al. reveal that a partnership between two condensates, Whi3 assemblies and P-bodies, forms a decision module in budding yeast that encodes aging information and enables context-dependent choices between proliferation, senescence, and mating.

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCellular SenescenceSaccharomyces cerevisiae Proteinscell fate decisioncondensatessenescence

Identifiers

PMID41916826
PMCPMC13045647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.