Evidence map›Paper›PMID 41916755›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson's Disease and in an α-Synuclein Mouse Model.

Nijee S Luthra, Luke W Bonham, Arturo J Moreno, Cana Park, Claire J C Huguenard, Samira Abdulai-Saiku, Shweta Gupta, Jonathan Lin, Lauren Broestl, Alexandre Bétourné and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nijee S LuthraDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158 dena.dubal@ucsf.edu nijee.luthra@ucsf.edu.
Luke W BonhamDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Arturo J MorenoDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Cana ParkDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Claire J C HuguenardDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Samira Abdulai-SaikuDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Shweta GuptaDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Jonathan LinDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Lauren BroestlDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Alexandre BétournéDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Rohan SehgalDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Dan WangDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Sylvain E LesnéDepartment of Neuroscience and Institute for Translational Neuroscience, The University of Minnesota, Minneapolis, Minnesota 55455.ORCID https://orcid.org/0000-0001-9411-1868
Jill L OstremDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Jennifer S YokoyamaDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158.
Dena B DubalDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California 94158 dena.dubal@ucsf.edu nijee.luthra@ucsf.edu.ORCID https://orcid.org/0000-0001-7504-4372

Funding

Enhancing Cognitive Resilience In Parkinson's Disease: Role Of Antiaging Protein KlothoK23NS123506 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nijee Luthra · 2022 to 2026
$952k
NINDS NIH HHS K23 NS123506
6 · The paper itself

Abstract

Aging is the primary risk factor for Parkinson's disease (PD), and PD-related cognitive impairment remains a major unmet biomedical challenge. Klotho, a pleiotropic protein, extends lifespan and enhances cognition, but whether it confers resilience to cognitive impairments in PD is unclear. Here, we show that in humans, the KL-VS genetic variant of

Indexed as

alpha-SynucleinCognitive DysfunctionGlucuronidaseKlotho ProteinsLongevityParkinson DiseaseAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, Transgenicalpha-SynucleinGlucuronidaseKlotho ProteinsKL protein, humanagingcognitionklotholongevityParkinson’s diseasesynuclein

Identifiers

PMID41916755
PMCPMC13325615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.