Evidence map›Paper›PMID 41916713›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2026

[Mechanism underlying carvacrol-induced alveolar bone repair via the phosphatidylinositol 3-kinase pathway in periodontal disease].

Nian Teng, Zhaoxun Li, Tiantian Gao, Yanrui Xiang, Lulu Zhou, Xiang Gao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nian TengCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Zhaoxun LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Tiantian GaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yanrui XiangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Lulu ZhouCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Xiang GaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to explore the mechanism of carvacrol (CV) in regulating alveolar bone repair in periodontal disease.

methodsA rat model of periodontal disease (P group) was created by ligating the first molar and injecting lipopolysaccharide (LPS). A control model (C group) was also created. The treatment models received low (L group), medium (M group), and high (H group) doses of CV hydrogel. Hematoxylin-eosin (HE) staining was used to observe the pathological changes in periodontal tissues. Immunohistochemical staining was employed to analyze the expression of collagen typeⅠ(COL1) and Runt-related transcription factor 2 (Runx2).

resultsCV hydrogel alleviated periodontal symptoms, upregulated PI3K/AKT/GSK-3β pathway-related and osteoblastic proteins, and increased the expression of ALP and the number of calcified nodules. However, it decreased cell apoptosis and inflammatory factors. LY294002 inhibited the PI3K/AKT pathway and decreased osteoblastic protein expression, ALP coloration, and calcified nodule quantity.

conclusionsCV hydrogel promotes the proliferation and differentiation of alveolar bone osteoblasts by activating the PI3K pathway and inhibiting inflammation-induced bone resorption. This study emphasizes the potential of CV for the treatment of periodontal diseases.

Indexed as

CymenesMonoterpenesPeriodontal DiseasesPhosphatidylinositol 3-KinaseAnimalsApoptosisCollagen Type ICore Binding Factor Alpha 1 SubunitGlycogen Synthase Kinase 3 betaOsteoblastsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductioncarvacrolCollagen Type ICore Binding Factor Alpha 1 SubunitCymenesGlycogen Synthase Kinase 3 betaMonoterpenesPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRunx2 protein, ratcarvacrollipopolysaccharideosteoblastsperiodontal diseasephosphatidylinositol 3-kinase

Identifiers

PMID41916713
PMCPMC13047892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.