ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2026
[Effect of Golgi membrane protein 1 on the proliferation, migration, and invasion of oral squamous cell carcinoma cells and its mechanism].
Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the expression of Golgi membrane protein 1 (GOLM1) in oral squamous cell carcinoma (OSCC) and its effects on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in OSCC cells and the underlying mechanisms.
methodsBioinformatics analysis was performed using the data from The Cancer Genome Atlas and Genotype-Tissue Expression databases to evaluate the expression of GOLM1 in head and neck squamous cell carcinoma (HNSCC) and its prognostic significance. Immunohistochemistry was used to detect GOLM1 expression in OSCC tissues and adjacent tissues. The mRNA and protein levels of GOLM1 in human normal oral keratinocytes (HOK) and OSCC cell lines (HSC-3 and SCC-25, respectively) were measured via real-time quantitative polymerase chain reaction (qRT-PCR) and Western blot. For
resultsGOLM1 exhibited a high expression in HNSCC, correlation with poor prognosis, and significant upregulation in OSCC tissues. In addition, GOLM1 showed markedly elevated expression levels in OSCC cell lines HSC-3 and SCC-25 compared with those in HOK cells. Silencing of GOLM1 markedly suppressed OSCC cell proliferation, migration, and invasion, accompanied with an increased E-cadherin expression and decreased N-cadherin and Vimentin levels. GSEA revealed a strong association between GOLM1 and the transforming growth factor-beta (TGF-β) signaling pathway. Silencing of GOLM1 reduced the expressions of TGF-β1, Smad2, and phosphorylated Smad2. Exogenous recombinant human TGF-β1 protein rescued the inhibitory effects of GOLM1 knockdown on OSCC cell proliferation, migration, and invasion.
conclusionsGOLM1 is overexpressed in OSCC tissues and cells, and silencing of this protein inhibits OSCC cell proliferation, migration, invasion, and EMT via the TGF-β1/Smad2 signaling pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.