Evidence map›Paper›PMID 41916687›Full record

ArticleBMJ open ophthalmology2026

Cystoid macular oedema after trabeculectomy versus tube shunt surgery in non-diabetic patients.

Abdelrahman M Elhusseiny, Hashem Abu Serhan, Taher K Eleiwa, Mohammad Ayoubi, Reem H ElSheikh, Muhammad Z Chauhan, Sami H Uwaydat, Mohsen Adelpour, Richard K Lee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdelrahman M ElhusseinyDepartment of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID http://orcid.org/0000-0003-1412-375X
Hashem Abu SerhanDepartment of Ophthalmology, Hamad Medical Corporation, Doha, Qatar.
Taher K EleiwaDepartment of Ophthalmology, Benha University, Banha, Egypt.
Mohammad AyoubiUniversity of Miami Miller School of Medicine, Miami, Florida, USA.ORCID http://orcid.org/0009-0001-3502-3478
Reem H ElSheikhDepartment of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Muhammad Z ChauhanDepartment of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Sami H UwaydatDepartment of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Mohsen AdelpourDepartment of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Richard K LeeDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA rlee@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo compare the hazard of postoperative cystoid macular oedema (CME) between trabeculectomy and tube shunt implantation, focusing exclusively on non-diabetic patients to minimise confounding factors.

methodsThis is a retrospective cohort study using the TriNetX United States Collaborative Network. Patients with glaucoma who underwent trabeculectomy or tube shunt surgery were identified via International Classification of Diseases, 10th Revision and Current Procedural Terminology codes. Propensity score matching (PSM) was used to balance baseline characteristics. The primary outcome was the hazard of CME at 1 and 3 months postoperatively. Adjusted HRs (aHRs) were calculated using Cox proportional hazards models.

resultsAfter 1:1 PSM, 2928 patients were included in each cohort. At 1 month, CME was significantly less frequent in the trabeculectomy group (1.15%) compared with the tube shunt group (1.85%) (p=0.02). This difference widened at 3 months, with CME rates of 2.19% in the trabeculectomy group vs 4.20% in the tube group (p<0.0001). Trabeculectomy was associated with a 35% reduction in CME hazard at 1 month (aHR: 0.64; 95% CI 0.44 to 0.94; p=0.023) and a 45% reduction at 3 months (aHR: 0.55; 95% CI 0.42 to 0.72; p<0.0001) compared with tube shunt surgery. Male sex (aHR: 1.32), topical alpha agonist use (aHR: 1.61) and macular puckering (aHR: 2.75) were independently associated with increased CME risk.

conclusionsTrabeculectomy is associated with a significantly lower hazard of postoperative CME compared with tube shunt surgery in non-diabetic glaucoma patients.

Indexed as

GlaucomaGlaucoma Drainage ImplantsMacular EdemaPostoperative ComplicationsTrabeculectomyVisual AcuityAgedFemaleFollow-Up StudiesHumansIncidenceIntraocular PressureMaleMiddle AgedRetrospective StudiesRisk FactorsGlaucomaMaculaOcular Hypertension

Identifiers

PMID41916687
PMCPMC13052526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.