Evidence map›Paper›PMID 41916475›Full record

ArticleEnvironmental research2026

Arsenic exposure at birth, socioeconomic status, and epigenetic aging among adults in northern Chile.

Dayoon Kwon, Anne K Bozack, Catterina Ferreccio, Nolan McCormick, Craig M Steinmaus, Rosemarie de la Rosa, Andres Cardenas

Abstract read
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In one paragraph

Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dayoon KwonDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Palo Alto, CA, USA. Electronic address: dayoonk@stanford.edu.
Anne K BozackDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, USA.
Catterina FerreccioSchool of Public Health, Pontificia Universidad Católica de Chile, Alameda 390, Santiago, Chile; The Chilean Institute of Public Health. Marathon 1000, Ñuñoa, Santiago, Chile.
Nolan McCormickDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Craig M SteinmausDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Rosemarie de la RosaDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Palo Alto, CA, USA.

Funding

PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
Programming of Epigenetic Clocks and Biomarkers from Early-life Arsenic ExposureR21ES035517 · NIEHS · STANFORD UNIVERSITY · PI CARDENAS, ANDRES, DE LA ROSA, ROSEMARIE · 2023 to 2024
$441k
NIEHS NIH HHS R01 ES031259NIEHS NIH HHS R21 ES035517
6 · The paper itself

Abstract

backgroundArsenic exposure remains a major global health concern, and early-life exposure has been linked to cancer, cardiovascular disease, and diabetes. Epigenetic biomarkers of aging may capture long-term effects of arsenic, yet whether exposure during sensitive developmental windows leaves detectable epigenetic signatures decades later remains unclear. Socioeconomic status (SES) may modify these relationships, yet its role as a modifier has not been examined.

methodsWe leveraged a natural experiment in northern Chile, where municipal drinking-water arsenic concentrations were extremely high from 1958 to 1972. Decades later, leukocyte DNA methylation was measured among 358 adults (mean age = 65.7 years) using the Illumina EPIC v2 array. Arsenic concentration at birth (0-860 μg/L) was assigned from historical water records. Current exposure was measured in urine (2-646 μg/g creatinine). We evaluated associations of birth and current arsenic exposure with epigenome-wide methylation and epigenetic aging, incorporating multiplicative interaction and stratification by SES.

resultsNo CpGs were linked to birth arsenic exposure, whereas nine CpGs passed the Bonferroni threshold for current urinary arsenic (p

conclusionEarly-life arsenic exposure was associated with accelerated epigenetic aging in adulthood, whereas current exposure was associated with CpG-specific methylation changes, particularly among socioeconomically disadvantaged individuals.

Indexed as

AgingArsenicEnvironmental ExposureEpigenesis, GeneticSocial ClassWater Pollutants, ChemicalAgedChileDNA MethylationFemaleHumansInfant, NewbornMaleMiddle AgedArsenicWater Pollutants, ChemicalAgingArsenicChemical exposuresEpigenomicsMethylationSES

Identifiers

PMID41916475
PMCPMC13108496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.