Evidence map›Paper›PMID 41916297›Full record

ArticleCell reports methods2026

3D imaging with enhanced transparency, signal-to-background ratios, and antigen detection using HyPer-3D.

Tansol Choi, Lauretta A Lacko, Neranjan de Silva, Nang Kham Hsi Liang, Ying Liu, Edgar A Jamies, Todd Evans, Romulo Hurtado

Abstract read
In one paragraph

Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tansol ChoiDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Lauretta A LackoDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA; Human Therapeutic Organoid Core Facility, Weill Cornell Medicine, New York, NY, USA.
Neranjan de SilvaThe Rockefeller University, New York, NY, USA.
Nang Kham Hsi LiangDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Ying LiuDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Edgar A JamiesDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA; Weill Cornell Center for Genomic Health, New York, NY, USA. Electronic address: tre2003@med.cornell.edu.
Romulo HurtadoDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA. Electronic address: roh2002@med.cornell.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Defining the onset and regulation of myogenic upper urinary tract physiologyR01DK133381 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Romulo Hurtado · 2024 to 2026
$2.3M
Negative feedback regulation of growth factor signaling in adult spermatogonial stem cellsR01HD101452 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R, LIU, YING · 2021 to 2025
$1.8M
Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cellsR21HD107212 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R, LIU, YING · 2023 to 2024
$463k
NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD101452NICHD NIH HHS R21 HD107212NIDDK NIH HHS R01 DK133381
6 · The paper itself

Abstract

We developed HyPer-3D (hydrogen peroxide-NaN

Indexed as

AntigensImaging, Three-DimensionalAnimalsHumansHydrogen PeroxideMiceSignal-To-Noise RatioZebrafishAntigensHydrogen Peroxide3D imagingautofluorescenceconfocal microscopyCP: imagingfluorescent reportershuman tissue imaginglight sheet microscopymultiplex immunofluorescenceoptical clearingsignal-to-backround ratiovolumetric imaging

Identifiers

PMID41916297
PMCPMC13107066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.