Evidence map›Paper›PMID 41915857›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.

Zishan Ahmad, Muthusamy Ramakrishnan, Rajeev K Varshney, Anwar Shahzad, Shamsur Rehman, Bijaya Pant, Qiang Wei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zishan AhmadState Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Bamboo Research Institute, Nanjing Forestry University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-6170-4608
Muthusamy RamakrishnanState Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Bamboo Research Institute, Nanjing Forestry University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-7819-339X
Rajeev K VarshneyWA State Agricultural Biotechnology Centre, Centre for Crop and Food Innovation, Food Futures Institute, Murdoch University, Murdoch, WA, Australia.ORCID https://orcid.org/0000-0002-4562-9131
Anwar ShahzadPlant Biotechnology Section, Department of Botany, Aligarh Muslim University, Aligarh, India.ORCID https://orcid.org/0000-0002-6526-9196
Shamsur RehmanState Key Laboratory of Wheat Improvement, Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang, Weifang, Shandong, China.
Bijaya PantCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0001-5614-6031
Qiang WeiState Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Bamboo Research Institute, Nanjing Forestry University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-5180-2087

Funding

Metasequoia Faculty Research Start-Up Funding 163100028Metasequoia Faculty Research Start-Up Funding 163100036National Natural Science Foundation of China 32071848National Natural Science Foundation of China 32471977Natural Science Foundation For Distinguished Young Scholars of Nanjing Forestry University JC2019004Natural Science Foundation of Jiangsu Province BK20231289Project for Ground breaking Achievements of Nanjing Forestry University 202211Young Foreign Talent Program QN2022014012LYoung Foreign Talent Program Y20240114
6 · The paper itself

Abstract

The WUSCHEL (WUS) transcription factor, long recognized as a master regulator of stem cell maintenance in the shoot apical meristem (SAM), has expanded in significance as a multifaceted tool in plant biotechnology. With an emphasis on its new uses in crop regeneration, somatic embryogenesis (SE), stress tolerance, and developmental regulation in cereals, legumes, and other plant species, this review summarizes recent developments on WUS function outside of Arabidopsis. We emphasize how insights from WUS biology can be translated into practical strategies to improve yield, adaptability, and resilience, while also enhancing in vitro tissue culture systems. The objective of this review is to establish WUS as a crucial molecular target for future crop genetic improvement and sustainable farming methods by highlighting the current knowledge gaps and suggesting future directions.

Indexed as

Arabidopsis ProteinsCrops, AgriculturalHomeodomain ProteinsStem CellsTranscription FactorsArabidopsisGene Expression Regulation, PlantPlants, Genetically ModifiedArabidopsis ProteinsHomeodomain ProteinsTranscription FactorsWUSCHEL protein, ArabidopsisCRISPR/Cascrop biotechnologygenetic engineeringregeneration competenceWUSCHEL

Identifiers

PMID41915857
PMCPMC13116129

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.