ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Engineering a Virus-Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enzymatic de novo DNA synthesis has gained increasing attention over the past decades, having emerged as a hotspot in synthetic biology. However, current research remains largely focused on animal-derived X-family DNA polymerases (PolXs), such as the extensively studied terminal deoxynucleotidyl transferases (TdTs) from vertebrates and the recently identified RvPolX from the invertebrate Ramazzottius varieornatus. In contrast, microbial PolXs have largely been overlooked, despite their potential in catalytic diversity and industrial applicability. Here, we report the discovery and rational engineering of FvPolX, a PolX enzyme derived from Faustovirus. Through protein engineering, we developed the FvPolX
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