Evidence map›Paper›PMID 41915742›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Convergence of external and internal stressors on a stress-responsive enhancer of the

ZiYu Chen, XiaoQi Chen, KaiBin Yang, HouDong Zhou, YaFei Zhang, Zhen Huang, YanDing Zhang, Ralf Paus, ZhiCao Yue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

ZiYu Chen *International Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.
XiaoQi Chen *International Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.
KaiBin Yang *International Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.
HouDong Zhou *International Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.
YaFei Zhang *International Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.
Zhen HuangInnovation and Transformation Center, Fujian-Macao Science and Technology Cooperation Base of Traditional Chinese Medicine-Oriented Chronic Disease Prevention and Treatment, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
YanDing ZhangFujian Key Laboratory of Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350117, China.
Ralf PausDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL 33125.
ZhiCao YueInternational Cancer Center, Department of Cell Biology and Medical Genetics, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China.ORCID 0000-0001-5729-3842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammals are constantly exposed to various stressors of internal and external origin. Though hair follicles (HFs) are exquisitely sensitive to stress, it remains largely unknown how stress-induced responses are linked with the intrinsic regulators of HF growth, cycling, and regeneration. Here, we characterize the long-range enhancer of

Indexed as

Enhancer Elements, GeneticHair FollicleHedgehog ProteinsStress, PhysiologicalAnimalsEarly Growth Response Protein 1MiceRegenerationEarly Growth Response Protein 1Egr1 protein, mouseHedgehog ProteinsShh protein, mouseEgr1enhancerhair follicleShhstress

Identifiers

PMID41915742
PMCPMC13056119

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.