Evidence map›Paper›PMID 41915471›Full record

ArticleCell reports2026

A neuropeptide regulates cell non-autonomous protein homeostasis.

Carrie A Sheeler, Jacqueline Y Lo, Areebah Rahman, Saebom Kwon, Daviana Menendez Escalera, Emmett Griffin-Baldwin, Karmen Mah, Adam Roszczyk, Jennifer L Garrison, Ashley E Frakes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Carrie A SheelerGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Jacqueline Y LoBuck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.
Areebah RahmanGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Saebom KwonGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Daviana Menendez EscaleraGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Emmett Griffin-BaldwinGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Karmen MahGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Adam RoszczykGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.
Jennifer L GarrisonBuck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.
Ashley E FrakesGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA; National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. Electronic address: ashley.frakes@nih.gov.

Funding

Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Glial regulation of ER stress resistanceZIADK075172 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI FRAKES, ASHLEY · 2022 to 2025
$11.7M
Cellular and Circuit Mechanisms of Neuropeptide SignalingR35GM145305 · NIGMS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GARRISON, JENNIFER L · 2022 to 2025
$2.0M
Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK075172NIA NIH HHS T32 AG000266NIGMS NIH HHS R35 GM145305
6 · The paper itself

Abstract

The coordination of proteostasis between the brain and peripheral tissues is essential for the health and survival of all animals. In C. elegans, glia coordinate organismal proteostasis and longevity via the unfolded protein response of the endoplasmic reticulum (UPR

Indexed as

C. eleganscell non-autonomous cellular signalingcellular stress responsesCP: cell biologyendoplasmic reticulumER stressglianeuronsneuropeptidesprotein homeostasisunfolded protein response

Identifiers

PMID41915471
PMCPMC13220339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.