Evidence map›Paper›PMID 41915426›Full record

ArticleThe Journal of clinical investigation2026

Tumor proliferation associates with greater sensitivity to androgen receptor pathway inhibition in metastatic prostate cancer.

Larissa Mendes, Peter F Dutey-Magni, Emily Grist, Ashwin Sachdeva, Sara Santos Vidal, Sharanpreet Lall, Marina A Parry, Claire L Amos, Nafisah Atako, Anna Wingate and 10 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Larissa MendesUniversity College London, London, United Kingdom.
Peter F Dutey-MagniUniversity College London, London, United Kingdom.
Emily GristUniversity College London, London, United Kingdom.
Ashwin SachdevaThe University of Manchester, Manchester, United Kingdom.
Sara Santos VidalUniversity College London, London, United Kingdom.
Sharanpreet LallUniversity College London, London, United Kingdom.
Marina A ParryUniversity College London, London, United Kingdom.
Claire L AmosUniversity College London, London, United Kingdom.
Nafisah AtakoUniversity College London, London, United Kingdom.
Anna WingateUniversity College London, London, United Kingdom.
Daniel WetterskogUniversity College London, London, United Kingdom.
Matthew R SydesUniversity College London, London, United Kingdom.
Chris C ParkerRoyal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom.
Noel ClarkeThe University of Manchester, Manchester, United Kingdom.
Christopher J SweeneyUniversity of South Australia, Adelaide, Australia.
Mahesh K ParmarUniversity College London, London, United Kingdom.
Louise C BrownUniversity College London, London, United Kingdom.
Nicholas D JamesRoyal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom.
Daniel M BerneyQueen Mary University London, London, United Kingdom.
Gerhardt AttardUniversity College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<article data-scroll-anchor="false" data-testid="conversation-turn-47" data-turn="user" data-turn-id="be25b520-cadc-4509-8230-4988b5406e4d" dir="auto" tabindex="-1"> Prostate cancers with high proliferation rates have shorter survival times but when spread has occurred (metastatic), there is increased sensitivity to hormone therapy with abiraterone. </article>.

Indexed as

Androgen Receptor AntagonistsAndrostenesCell ProliferationProstatic NeoplasmsReceptors, AndrogenSignal TransductionHumansMaleNeoplasm MetastasisabirateroneAndrogen Receptor AntagonistsAndrostenesAR protein, humanReceptors, AndrogenBiomarkersClinical ResearchClinical trialsOncologyProstate cancer

Identifiers

PMID41915426
PMCPMC13178641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.