ArticleMolecular neurobiology2026
Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recent Advances in Diversified Materials for Spinal Cord Injury Repair and Regeneration.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Spinal cord injury (SCI) causes irreversible motor dysfunction, with reactive astrocytes contributing significantly to the secondary injury cascade. Neuronal stem cell (NSC)-derived exosomes have recently emerged as therapeutic carriers for functional microRNAs (miRNAs) in the central nervous system (CNS), yet their regulatory effects on astrocyte phenotypes in SCI remain unclear. We utilized in vivo and in vitro models of SCI to evaluate the therapeutic potential of NSC-derived exosomes. Microarray profiling was performed to identify exosomal miRNAs, followed by mechanistic validation using bioinformatics, RNA immunoprecipitation (RIP), luciferase reporter assays, and Western blotting. Functional outcomes were assessed by behavioral tests and rescue experiments in SCI mice. NSC-derived exosomes significantly enhanced motor recovery after SCI by shifting astrocytes from the A1-reactive phenotype to the neuroprotective A2-like properties. miR-31-5p was identified as the most enriched miRNA in exosomes and was found to directly target interleukin-34 (Il34), thereby downregulating the Il34/Stat3 signaling axis in astrocytes. Rescue assays confirmed that miR-31-5p-mediated suppression of Il34/Stat3 facilitates astrocytic phenotypic modulation and neurorepair. Our findings uncover a novel mechanism by which exosomal miR-31-5p modulates astrocyte phenotypes via the Il34/Stat3 pathway, highlighting its therapeutic potential as a miRNA-based intervention for promoting functional recovery after SCI.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.