Evidence map›Paper›PMID 41915332›Full record

ReviewCurrent cardiology reports2026

Non-Dilated Left Ventricular Cardiomyopathy (NDLVC): A Name, Multiple Souls.

Andrea Villatore, Emanuela Sergianni, Alessia F Trezza, Matteo A di Padova, Chiara Amman, Chiara Fiorentino, Emanuela Favalli, Francesca Rumore, Paolo Della Bella, Giovanni Peretto

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea VillatoreMultidisciplinary Disease Unit for Myocarditis and Arrhythmogenic Cardiomyopathies, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.ORCID http://orcid.org/0000-0002-2858-1404
Emanuela SergianniFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Alessia F TrezzaFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Matteo A di PadovaFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Chiara AmmanFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Chiara FiorentinoFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Emanuela FavalliFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Francesca RumoreFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132, Milan, Italy.
Paolo Della BellaCardiac Electrophysiology Department, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.ORCID http://orcid.org/0000-0001-8346-1387
Giovanni PerettoMultidisciplinary Disease Unit for Myocarditis and Arrhythmogenic Cardiomyopathies, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy. peretto.giovanni@hsr.it.ORCID http://orcid.org/0000-0003-1815-4000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewNon-dilated left ventricular cardiomyopathy (NDLVC) is a newly recognized cardiomyopathy phenotype, characterized by systolic dysfunction and/or non-ischemic myocardial scar, in the absence of ventricular dilatation. This review summarizes current evidence on its epidemiology, imaging features, genetic background, arrhythmic substrate, differential diagnosis, risk stratification, and management. RECENT

findingsAdvanced cardiac magnetic resonance has demonstrated that late gadolinium enhancement, particularly septal and ring-like pattern, is common in NDLVC and predicts malignant ventricular arrhythmias (MVA) and evolution to dilated phenotype. High-risk genotypes (e.g., DSP, FLNC, LMNA, PLN) and myocardial inflammation further increase arrhythmic and heart failure risk. Novel tools, including the NDLVC-5-year risk score, allow improved individualized prediction, especially when combined with genotype-specific score. NDLVC resulting from the complex interplay between genetic background and environmental factors may lead to arrhythmias and heart failure. A multimodal, phenotype-first approach integrating imaging, genetics, and electrophysiology is essential for accurate diagnosis, risk stratification, and personalized management.

Indexed as

CardiomyopathiesVentricular Dysfunction, LeftArrhythmias, CardiacDiagnosis, DifferentialHeart FailureHumansPhenotypeRisk AssessmentRisk FactorsCardiomyopathyHeart failureNDLVCNon-dilated left ventricular cardiomyopathyVentricular arrhythmias

Identifiers

PMID41915332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.