Evidence map›Paper›PMID 41915255›Full record

ArticleActa parasitologica2026

Therapeutic Impact of Plant-Derived Extracts and their Silver Nanoparticle-Loaded Extracts on the Zoonotic Parasite Hymenolepis Nana Infection.

Wesam M A Elgendy, Hany M El-Wahsh, Doaa Naguib, Rasha A Elmahy, Suzan Awad AbdelGhany Morsy, Ashraf Fawzy Mosa Ahmed, Marim Fayz Abdow, Nabeel Hussain Alhussainy, Faten Abdullah Al Braikan, Ahmed Bendari and 2 more

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Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wesam M A ElgendyMedical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Hany M El-WahshMarine Biology Department, Faculty of Marine Sciences , King Abdulaziz University, Jeddah, Saudi Arabia.
Doaa NaguibDepartment of Hygiene and Zoonoses, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. doaanaguib246@yahoo.com.
Rasha A ElmahyZoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Suzan Awad AbdelGhany MorsyDepartment of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Dr Fahmi Abdelmeguid St., Mowassah campus, Alexandria, Alexandria 21561, Egypt.
Ashraf Fawzy Mosa AhmedMolecular and Applied Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Marim Fayz AbdowAnatomy and Embryology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Nabeel Hussain AlhussainyDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Faten Abdullah Al BraikanDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmed BendariDepartment of Pathology and Laboratory Medicine, Lenox Hill Hospital, New York City, USA.
Akram Abu-OkailDepartment of Pathology and Laboratory Diagnosis, College of Veterinary Medicine, Qassim University, Buraydah, 52571, Al-Qassim, Saudi Arabia.
Amira Mohamed AbdelHady ElhosyniColleague in Biochemistry and Clinical Laboratory Sciences, Faculty of Medicine, Mansoura University, Al-Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHymenolepis nana (H. nana) is a neglected zoonotic cestode that commonly infects humans and is typically treated with praziquantel (PZQ). Due to concerns about drug resistance and adverse effects, this study explored the antiparasitic activity of aqueous extracts from Artemisia alba, Moringa oleifera, and Ceratonia siliqua, as well as their corresponding silver-nanoparticles (AgNPs)-loaded extracts, against H. nana infection.

methodsTen groups of male albino mice were used: a healthy control group, an infected untreated group, and six infected groups treated with the aqueous extracts of A. alba, M. oleifera, and C. siliqua, along with their silver nanoparticle-loaded extracts. Two additional infected groups received either AgNPs alone or PZQ. The study assessed parasitological parameters, particularly egg count per gram (EPG), alongside jejunal histopathology and liver and kidney function markers.

resultsAll treated groups exhibited a significant reduction in H. nana infection. Both forms of A. alba, as well as AgNPs and PZQ, achieved a complete (100%) reduction in fecal EPG. In contrast, the aqueous extracts of M. oleifera and C. siliqua produced a 75% reduction. AgNPs and PZQ did not improve renal or hepatic function. All plant extracts demonstrated hepatoprotective effects, while the aqueous and AgNPs-loaded extracts of A. alba and M. oleifera also showed renoprotective activity.

conclusionAqueous extracts of Artemisia alba, Moringa oleifera, and Ceratonia siliqua, along with their AgNPs-loaded counterparts, exhibited significant antiparasitic effects against H. nana. Among them, A. alba showed the highest efficacy in both its extract and AgNPs-loaded extract.

Indexed as

AnthelminticsHymenolepiasisHymenolepis nanaMetal NanoparticlesPlant ExtractsSilverAnimalsArtemisiaMaleMiceMoringa oleiferaParasite Egg CountPraziquantelAnthelminticsPlant ExtractsPraziquantelSilverArtemisia albaCeratonia siliquaHymenolepis nanaMoringa oleiferaSilver nanoparticlesZoonoses

Identifiers

PMID41915255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.