ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Anti-tumor effects and immuno-inflammatory-metabolic mechanisms of Buzhong Yiqi Granules in improving cancer-related fatigue in lung cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the anti-tumor effects and immuno-inflammatory-metabolic mechanisms of Buzhong Yiqi Granules (BYG) in alleviating cancer-related fatigue (CRF) in lung cancer.
methodsUPLC-Q-TOF/MS detected compounds in BYG. CRF was induced in mice via Lewis lung carcinoma cell inoculation, with daily BYG treatment for 14 days. Anti-fatigue efficacy was evaluated through behavioral tests and ATP content detection. Anti-tumor effects were assessed via histopathology, tumor volume, and weight. Immuno-inflammatory-metabolic mechanisms were evaluated using inflammatory cytokines (IL-6, TNF-α, IFN-γ) and immune cell subsets (CD4+, CD8+ T cells) in serum and tumor tissues.
resultsNinety-four active compounds were identified in BYG. In the CRF mouse model, BYG prolonged swimming time, reduced tail suspension immobility, increased muscle ATP to exert anti-fatigue effects; it inhibited tumor growth and metastasis by reducing volume and downregulating EGFR/CD34/MMP-9; it also modulated inflammation and immunity by lowering IL-6/TNF-α, elevating IFN-γ, enhancing CD4 + T cells and restoring the CD4 + /CD8 + ratio.
conclusionsBYG alleviates CRF via multi-target mechanisms involving energy metabolism, tumor inhibition, and immune-inflammatory regulation, supporting its clinical use in CRF and potential as lung cancer adjuvant therapy.
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