Evidence map›Paper›PMID 41915239›Full record

ArticleMolecular genetics and genomics : MGG2026

The role of apoptotic genetic polymorphisms in prostate cancer susceptibility in a North West Spain population.

N López-Trigo, B Caeiro, J Pérez-Pérez, A Rodríguez-Alonso, N Aguín, J A Rodríguez, J R Luis

Abstract read
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Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N López-TrigoÁrea de Antropoloxía Física, Facultade de Bioloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, 15702, Spain. nuria.lt@hotmail.com.ORCID http://orcid.org/0000-0002-3694-7146
B CaeiroÁrea de Antropoloxía Física, Facultade de Bioloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, 15702, Spain.
J Pérez-PérezServicio de Uroloxía, Hospital Arquitecto Marcide, Ferrol, Galicia, 15405, Spain.
A Rodríguez-AlonsoServicio de Uroloxía, Hospital Arquitecto Marcide, Ferrol, Galicia, 15405, Spain.
N AguínÁrea de Antropoloxía Física, Facultade de Bioloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, 15702, Spain.
J A RodríguezCenter for Evolutionary Hologenomics, The Global Institute, University of Copenhagen, Copenaghen, 1350, Denmark.
J R LuisÁrea de Antropoloxía Física, Facultade de Bioloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, 15702, Spain.

Funding

Asociación Española de Urología Asociación Española de Urología
6 · The paper itself

Abstract

Apoptosis and tumor suppression prevent cell proliferation in response to genomic damage. Polymorphisms in genes involved in these pathways can alter their function, facilitating the onset of cancer. Detecting these polymorphisms would assess the individual risk of developing different types of cancer. Therefore, the main goal of this study is to analyze the association between a set of genetic polymorphisms involved in apoptosis and tumor suppression and the risk of developing prostate cancer (PCa) in a population from Galicia. Accordingly, we performed a case-control study with 291 patients diagnosed with PCa and 249 healthy controls. A total of 19 genetic polymorphisms located in loci BCL2, CASP9, CASP8, CASP7, FAS, FASLG, BIRC5, TP53, MDM2, and MDM4 were genotyped. Their association with PCa was approached from a global perspective and stratified by the body mass index (BMI). Globally, a statistically significant association with PCa was found for polymorphisms rs1052576 (CASP9) and rs990431 (BIRC5), with carriers of the G allele (OR

Indexed as

ApoptosisGenetic Predisposition to DiseasePolymorphism, Single NucleotideProstatic NeoplasmsAgedAllelesBody Mass IndexCase-Control StudiesGenotypeHumansMaleMiddle AgedRisk FactorsSpainApoptosisCase control studyGenetic polymorphismProstate cancerRisk factorsTP53

Identifiers

PMID41915239

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.