Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jo A KellyWake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Mark C ChappellDepartment of Surgery, Section of Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Elizabeth T JensenDivision of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Keia R SandersonDepartment of Pediatrics, Division of Pediatric Nephrology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Christopher L SchaichDepartment of Surgery, Section of Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Hossam A ShaltoutDepartment of Surgery, Section of Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Andrew M SouthDepartment of Surgery, Section of Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. Andrew.South@wfusm.edu.ORCID http://orcid.org/0000-0002-3204-4142
Funding
The Impact of Antenatal Steroid Exposure on the Intrarenal Renin-Angiotensin SystP01HD047584 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSE, JAMES C. · 2005 to 2016
$13.0M
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born PretermR01HL146818 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, SHALTOUT, HOSSAM · 2019 to 2023
$4.0M
Developmental Origins of Cardiovascular Disease in Offspring from Non-Human Primate Pregnancies at Advanced Maternal AgeR01HL164434 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Sarah N Cilvik · 2023 to 2026
$3.0M
Wake Forest Short-term Research Training ProgramT35DK007400 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DONALD A. MCCLAIN · 1986 to 2026
$1.9M
Dysfunctional Renin-Angiotensin System in Septic ShockR01HL177834 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MARK C CHAPPELL, Ashish K Khanna · 2025 to 2026
$1.5M
The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damageK23HL148394 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOUTH, ANDREW MICHAEL · 2020 to 2024
$783k
Novel Angiotensin-(1-7) Endopeptidase in Fetal ProgrammingR21HD084227 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, ROSE, JAMES C. · 2016 to 2017
$426k
American Heart Association 14GRNT20480131American Heart Association 18TPA34170522Eunice Kennedy Shriver National Institute of Child Health and Human Development P01HD047584Eunice Kennedy Shriver National Institute of Child Health and Human Development P01HD084227NHLBI NIH HHS K23 HL148394NHLBI NIH HHS K23HL148394NHLBI NIH HHS R01 HL146818NHLBI NIH HHS R01HL146818NHLBI NIH HHS R01 HL164434NHLBI NIH HHS R01HL164434NHLBI NIH HHS R01 HL177834NHLBI NIH HHS R01HL177834NICHD NIH HHS P01 HD047584NICHD NIH HHS R21 HD084227NIDDK NIH HHS T35 DK007400NIDDK NIH HHS T35DK007400
6 · The paper itself
Abstract
backgroundTo estimate the association of hypertensive disorders of pregnancy (HDP) with offspring kidney function in adolescence and young adulthood in individuals born preterm with very low birth weight.
methodsSecondary analysis of data from a prospective cohort study of individuals born preterm with very low or extremely low birth weight (< 1500 g). The 213 participants were assessed at 14-15 and 19-23 years of age. Outcomes were estimated glomerular filtration rate (eGFR) and first-morning urine albumin-to-creatinine ratio (ACR). We estimated the relationships with multivariable generalized linear models informed by directed acyclic graphs. Causal mediation analysis was also performed to evaluate if adolescent kidney function indirectly mediated the effect of HDP on young adulthood kidney function.
resultsThirty-seven percent (n = 79) were exposed to HDP. Kidney function in adolescence was associated with kidney function in young adulthood (eGFR adjusted β 0.48 mL/min/1.73 m
conclusionsWe found no significant association between HDP and offspring kidney function in adolescence and young adulthood and no evidence of mediation through adolescent kidney function. Next steps in this research may look to investigate the relationship of severity of prematurity on offspring kidney function, as HDPs are a factor in premature births and the degree of prematurity.
Indexed as
Hypertension, Pregnancy-InducedKidneyPrenatal Exposure Delayed EffectsAdolescentAlbuminuriaCreatinineDevelopmental Origins of Health and DiseaseFemaleGlomerular Filtration RateHumansInfant, NewbornInfant, Very Low Birth WeightMalePregnancyProspective StudiesYoung AdultCreatinineCausal inferenceCausal mediation analysisDirected acyclic graphsOrganogenesisPediatric nephrologyPediatricsPregnancy complications
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Estimating the association of hypertensive disorders of pregnancy with offspring kidney function from adolescence into young adulthood. · full record | OpenQuestion