Evidence map›Paper›PMID 41915187›Full record

ArticleArchives of toxicology2026

Formation and persistence of estragole-derived DNA adducts in human liver cells and tissue.

G Ackermann, M Abel-Beckmann, C Quarz, M Halaczkiewicz, S Stegmüller, E Richling, G Manolikakes, M Christmann, J H Küpper, D Schrenk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

G AckermannDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
M Abel-BeckmannDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
C QuarzDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
M HalaczkiewiczDivision of Organic Chemistry, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin‑Schrödinger‑Str. 54, 67663, Kaiserslautern, Germany.
S StegmüllerDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
E RichlingDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
G ManolikakesDivision of Organic Chemistry, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin‑Schrödinger‑Str. 54, 67663, Kaiserslautern, Germany.
M ChristmannInstitute of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131, Mainz, Germany.
J H KüpperDivision of Molecular Cell Biology, Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Universitätsplatz 1, 01968, Senftenberg, Germany.
D SchrenkDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany.
J FahrerDivision of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Erwin-Schrödinger-Str. 52, 67663, Kaiserslautern, Germany. joerg.fahrer@chem.rptu.de.ORCID 0000-0001-5225-2718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estragole (ES) is a phenylpropene naturally occurring in various herbs and spices, such as fennel and basil. Humans are exposed to ES via the diet or herbal medicinal products. Following its gastrointestinal resorption, hepatic bioactivation of ES by Cytochrome P450 monooxygenases (CYPs) and sulfotransferases (SULTs) can lead to DNA adduct formation and liver cancer in rodents. Up to now, no data is available on ES-dependent DNA adducts in human tissue, which would however be important for human risk assessment. Our work thus analyzed whether ES-derived DNA adducts are present in human liver samples. Furthermore, DNA adduct formation after repetitive ES exposure and upon incubation with an ES-containing bitter fennel infusion was studied in human liver cells. Using a sensitive UHPLC-MS/MS method, we detected E3'-N

Indexed as

AnisolesDNA AdductsHepatocytesLiverAllylbenzene DerivativesArylsulfotransferaseChromatography, High Pressure LiquidCytochrome P-450 CYP1A2DeoxyguanosineFoeniculumHumansMaleTandem Mass SpectrometryAllylbenzene DerivativesAnisolesArylsulfotransferaseCYP1A2 protein, humanCytochrome P-450 CYP1A2DeoxyguanosineDNA AdductsestragoleSULT1A1 protein, humanBitter fennel oilDNA adductsEstragoleGenotoxicityHepatotoxicityHuman liver tissueLiver cellsPhenylpropenesRepetitive exposure

Identifiers

PMID41915187
PMCPMC13309446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.