In one paragraphArticle in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Patrycja M ForsterDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9688-0203 Alexandra PreußerDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-8539-9342 Hiroshi YanoJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.ORCID 0000-0002-3098-2629 Divija DeshpandeDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-9166-2509 Wen ZhangJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.ORCID 0000-0002-9069-3773 Anita KowalczykDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-4217-8857 Laura VellemanDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0002-7347-8067 Magdalena O DubikDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-4521-0410 Jazib UddinJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.ORCID 0000-0001-5303-5213 Elizabeth R EmanuelJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.ORCID 0000-0003-1532-8618 Pierre S LeclèreDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-1794-9461 Richard MertensDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9473-8422 Xuemei GaoDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-2949-3609 Michael Kofoed-BranzkDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-7210-3752 Anja E HauserDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association , Berlin, Germany.ORCID 0000-0002-7725-9526 Hans-Willi MittrückerDepartment of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-6166-4191 Andreas DiefenbachDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9176-9530 David ArtisJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.ORCID 0000-0003-3608-1044 Christoph S N KloseDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-8803-2979 Funding
Charité - Universitätsmedizin BerlinCrohn's and Colitis Foundation Research Fellowship 901000Crohn's and Colitis Foundation Research Fellowship 937437Einstein Foundation BerlinEuropean Research Council 803087European Research Council AdG 10105309German Research Foundation 511083451German Research Foundation 533770413German Research Foundation B05 - Project-ID 375876048 - CRC/TRR 241German Research Foundation CRC/TR 241/375876048German Research Foundation DI 764/12-1German Research Foundation FOR 2599-DI764/10-2German Research Foundation FOR2599 project 5German Research Foundation INST 335/597-1 FUGGGerman Research Foundation INST 335/777-1 FUGGGerman Research Foundation INST 335/845-1 FUGGGerman Research Foundation KL 2963/5-2German Research Foundation SPP 1937-DI764/9-2German Research Foundation SPP1937 - KL 2963/3-1Lundbeck Foundation R480-2024-1281Rosanne H. Silbermann FoundationSanders FamilyUS National Institutes of Health AI095466US National Institutes of Health AI095608US National Institutes of Health AI151599US National Institutes of Health AI172027US National Institutes of Health AR070116US National Institutes of Health DK126871US National Institutes of Health DK132244US National Institutes of Health K99AI180354US National Institutes of Health K99DK138295US National Institutes of Health U01AI095608-15S1Weill Cornell Medicine
6 · The paper itselfAbstract
Type 2 immunity has evolved to protect against worms but becomes harmful when activated during allergic inflammation. Group 2 innate lymphoid cells (ILC2s) drive type 2 responses by rapidly secreting IL-5 and IL-13. The alarmins, IL-25, IL-33, and TSLP activate ILC2s and are linked to allergic diseases. However, how alarmins connect to the transcriptional networks driving type 2 effector functions remains elusive. Here, we performed RNA sequencing of ILC2s deficient in IL-25, IL-33, or TSLP pathway and identified the transcription factor Blimp-1 as an IL-33-regulated gene in ILC2s. While Blimp-1 was dispensable for ILC2 development, this transcription factor was required for type 2 cytokine production, driving eosinophilia or promoting worm expulsion. Blimp-1 deficiency resulted in reduced IRF4 expression, while Irf4-deficient ILC2s showed diminished Blimp-1 and IL-33 receptor expression, revealing a reciprocal Blimp-1-IRF4 circuit downstream of the IL-33 receptor. These findings expose the Blimp-1-IRF4 axis as an alarmin-regulated transcriptional network controlling ILC2 effector functions required for type 2 immunity.
Indexed as
AlarminsImmunity, InnateLymphocytesPositive Regulatory Domain I-Binding Factor 1AnimalsCytokinesInflammationInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-33MiceMice, KnockoutSignal TransductionAlarminsCytokinesInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-33Positive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouse
Identifiers
PMID41915169
PMCPMC13037585
What OpenQuestion holds
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LicenceCC BY
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