Evidence map›Paper›PMID 41915135›Full record

ArticleMaternal and child health journal2026

Acceptability of Neuroimaging and Hormonal Biomarker Collection in Early Behavioral Intervention Research.

Angela Deotto, Giulia F Fabiano, Janaksha Linga-Easwaran, Steven P Miller, Evdokia Anagnostou, Elizabeth Kelley, Jennifer Crosbie, Rob Nicolson, Tricia S Williams

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In one paragraph

Article in Maternal and child health journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angela DeottoDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada. angela.deotto@gmail.com.ORCID http://orcid.org/0000-0002-9774-7658
Giulia F FabianoDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Janaksha Linga-EaswaranDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Steven P MillerFaculty of Medicine, BC Children's Hospital, Vancouver, BC, Canada.
Evdokia AnagnostouDepartment of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Elizabeth KelleyDepartments of Psychology and Psychiatry, Queens University, Kingston, ON, Canada.
Jennifer CrosbieDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.
Rob NicolsonDepartment of Psychiatry, Western University, London, ON, Canada.
Tricia S WilliamsDepartment of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.

Funding

Canadian Institutes of Health Research (CIHR) Operating Grant 178854]
6 · The paper itself

Abstract

purposeDespite its high relevance, there is little data surrounding parent acceptability of research that involves neurobiological data collection. The present mixed-method study examined parent acceptability of neuroimaging and hormonal biomarker collection in the context of an evidence-based child-focused intervention.

methodsParent participants (N = 173) were recruited from prior hospital-based studies that did not involve biomarker collection, including a clinical-research parenting program designed to treat child behavioral challenges in at-risk groups. Parents answered survey questions, detailing perspectives on research-based brain neuroimaging and hormonal biomarker collection in children and caregivers. Analyses adopted a mixed-methods approach to assess both quantitative and qualitative data.

resultsHalf or more parent participants indicated interest in the proposed methodologies, with high acceptability reflected in themes surrounding knowledge translation and indicators of child functioning and treatment effectiveness. Expressed concerns surrounded procedure tolerability, timing, and data privacy. Acceptability was highest among parents who concurrently reported elevated child behavior problems and parental mental health stress. Acceptability was also highest for saliva cortisol collection due to procedure ease.

conclusionsNeuroimaging and hormonal biomarker collection appear promising for capture of brain and physiologic plasticity in neurologically at-risk children and their caregivers. Future efforts should focus on procedure transparency and sensitively adapting methodologies to meet patient and family needs.

Indexed as

BiomarkersEarly Intervention, EducationalNeuroimagingParentsPatient Acceptance of Health CareAdultChildChild, PreschoolFemaleHumansHydrocortisoneMaleParentingSalivaSurveys and QuestionnairesBiomarkersHydrocortisoneAcceptabilityChild mental healthCortisol biomarkerNeuroimaging biomarkerParenting intervention

Identifiers

PMID41915135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.