Evidence map›Paper›PMID 41915086›Full record

ArticleAnnals of surgical oncology2026

Geographic Differences in Patient Experience After a Diagnosis of Lobular Breast Cancer.

Alexis Graham-Stephenson, Claire E Fanning, Esther L Geven, Flora Migyanka, Jacqueline S Jeruss

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexis Graham-Stephenson *Department of Surgical Oncology, Brigham and Women's Hospital, Boston, MA, USA.
Claire E Fanning *University of Michigan Medical School, Ann Arbor, MI, USA.
Esther L GevenDutch Lobular Breast Cancer Foundation, Sneek, The Netherlands.
Flora MigyankaThe Dynami Foundation, Plymouth, MI, USA.
Jacqueline S JerussUniversity of Michigan Medical School, Ann Arbor, MI, USA. jjeruss@med.umich.edu.

Funding

Tissue engineering tools for monitoring the cellular and molecular response to therapyR01CA272940 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, Lonnie D Shea · 2023 to 2026
$1.7M
Nanoparticles to reprogram innate immune cells and disrupt the metastatic nicheR01EB036030 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, Lonnie D Shea · 2024 to 2026
$1.5M
Injectable scaffolds for early detection of immune dysregulation and monitoring response to immunotherapiesU01EB036955 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, Lonnie D Shea · 2025 to 2026
$1.1M
NCI NIH HHS R01 CA272940NIBIB NIH HHS R01 EB036030NIBIB NIH HHS U01 EB036955NIH HHS R01CA272940NIH HHS R01EB036030NIH HHS U01EB036955
6 · The paper itself

Abstract

backgroundInvasive lobular breast carcinoma (ILC) has a distinct morphology and complex impact on clinical outcomes. In North America (NA) and Europe, geographic disparities in the management of ILC may contribute to stress experienced by patients. This study examined regional factors associated with ILC diagnosis that affected patient management and survivorship.

methodsA 31-item questionnaire was distributed to three moderated ILC patient groups. The survey consisted of demographic, Likert, multiple choice, and free response questions. Statistical analysis included chi-squared, Mann-Whitney U, and unpaired two-sample t-testing. P-values <0.05 were significant. Free responses were analyzed for theme identification. The study was exempt from institutional review board approval.

resultsParticipants (902) responded from 18 countries in Europe (n = 267) and NA (n = 635). Stage at diagnosis in Europe vs. NA was I, 23.6 vs. 48.9%; II, 54.1 vs. 30.5%; III, 17.9 vs. 17.0%; and IV, 4.5 vs. 3.7%. European patients had more advanced disease, and initial treatment recommendations more frequently included antihormonal therapy or chemotherapy (p <0.001). European patients were less frequently offered lumpectomy (p = 0.01). European respondents reported less emotional support from family (p = 0.003), employers (p = 0.004), and healthcare providers (p <0.001). NA respondents reported decreased confidence in the accuracy of medical follow-up (p <0.001). Shared themes included anxiety, lack of ILC-specific information relayed by providers, and perceived dismissal by providers.

conclusionsAlthough unique differences exist between regions, negative psychological implications associated with ILC are universal. This study provides insight into opportunities for global improvement in ILC management, including improved screening approaches and psychological support.

Indexed as

Breast NeoplasmsCarcinoma, LobularHealthcare DisparitiesAdultAgedEuropeFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm StagingNorth AmericaPrognosisStress, PsychologicalSurveys and QuestionnairesBreast cancerEuropeGlobal health disparitiesInvasive lobular carcinomaNorth AmericaPatient experiencePsychological stress

Identifiers

PMID41915086
PMCPMC13242493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.