Evidence map›Paper›PMID 41914745›Full record

ArticleMicrobiology spectrum2026

Lem3, a phospholipid flippase subunit, influences

Pranjali Agrawal, Pritam Kumar, Basharat Ali, Sunna Nabeela, Mélanie A C Ikeh, Joachim Morschhäuser, David R Andes, Clarissa J Nobile, Rajendra Prasad, Priya Uppuluri and 1 more

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pranjali AgrawalYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Pritam KumarYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Basharat AliYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.ORCID 0009-0009-8266-8605
Sunna NabeelaDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.
Mélanie A C IkehDepartment of Molecular and Cell Biology, University of California, Merced, California, USA.
Joachim MorschhäuserInstitute of Molecular Infection Biology, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-4227-8687
David R AndesDepartment of Medicine, Section of Infectious Diseases, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-7927-9950
Clarissa J NobileDepartment of Molecular and Cell Biology, University of California, Merced, California, USA.ORCID 0000-0003-0799-6499
Rajendra PrasadAmity Institute of Biotechnology, Amity University Gurugram, Gurugram, Haryana, India.ORCID 0000-0002-8044-7042
Priya UppuluriDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.ORCID 0000-0002-5889-054X
Sneh Lata PanwarYeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.ORCID 0000-0003-0848-8306

Funding

Vesicle-mediated drug resistance of Candida albicans biofilmR01AI073289 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, MITCHELL, AARON P · 2008 to 2025
$7.9M
NIAID NIH HHS R01 AI073289
6 · The paper itself

Abstract

Flippases, composed of catalytic and regulatory subunits, preserve cellular integrity by maintaining the asymmetric distribution of phospholipids across the plasma membrane. Here, we provide the first functional characterization of Lem3, the regulatory subunit of the flippase complex in IMPORTANCE: Plasma membrane lipid composition, maintained by lipid translocators, is a key determinant of virulence in pathogenic fungi. Here, we demonstrate that Lem3, the regulatory subunit of the flippase complex, by regulating the asymmetric distribution of phospholipids, impacts the expression of virulence traits and modulates drug resistance in

Indexed as

biofilmsCandida albicansflippaseLem3oropharyngeal candidiasisP4-type ATPasesvirulence

Identifiers

PMID41914745
PMCPMC13141972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.