SynthesisEuropean journal of neurology2026
Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single-Centre Cohort and Systematic Review With Meta-Analysis.
Synthesis in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Imaging and procedural features of staged bilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor.Frontiers in radiology · 2026Article
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Authors and funding
19 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundStaged bilateral Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy is an incisionless option for medication-refractory essential tremor (ET). While the efficacy and safety of unilateral MRgFUS are established, evidence for bilateral treatment remains limited.
objectiveTo evaluate the efficacy and safety of staged bilateral MRgFUS in a prospective single-centre observational cohort and to perform a systematic review and meta-analysis of the literature.
methodsConsecutive ET patients undergoing second-side MRgFUS were prospectively assessed. The primary efficacy endpoint was the longitudinal change in Clinical Rating Scale for Tremor (CRST) A + B scores for the treated hand after FUS2, while safety was evaluated by collecting and grading adverse events (AEs). A systematic review identified published bilateral MRgFUS series; efficacy data were meta-analysed, while AEs were reported descriptively.
resultsFifteen patients (60% men; mean age 74.1 ± 8.9 years) underwent FUS2 28.9 ± 22.5 months after first-side treatment. At the 12-month evaluation, CRST A + B decreased from 21.0 to 8.8 (-58%), CRST C from 7.3 to 1.9 (-74.2%), and QUEST from 30.5 to 9.5 (-68.7%). Head and voice tremor were reduced by 73.8% and 40.3%, respectively. AEs were predominantly mild (95.2%) and transient (88%). Cognition at 1 year was globally preserved, with a selective decline in verbal episodic memory. Meta-analysis confirmed significant improvement in tremor severity.
conclusionStaged bilateral MRgFUS thalamotomy was associated with sustained tremor reduction, including midline tremor, functional improvement and acceptability, with a manageable safety profile. Overall, consistent with literature, these findings support its potential role as a therapeutic option in selected ET patients.
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