ArticleThoracic research and practice2026
Seasonal Oxidative Stress and Airway Reactivity in Rhinitis: Distinct Patterns in Allergic vs. Non-allergic Individuals.
Article in Thoracic research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveRhinitis is a common upper airway disorder, classified as either allergic rhinitis (AR) or non-allergic rhinitis (NAR). While the association between air pollution and AR airway diseases has been well documented, its specific effects on NAR remain poorly understood. This study aimed to evaluate the seasonal impact of air pollution on pulmonary function, oxidative stress biomarkers, and bronchial hyperresponsiveness in patients with AR, patients with NAR, and healthy controls. MATERIAL AND
methodsIn this prospective case-control study, 58 participants (23 AR, 22 NAR, 13 controls) were evaluated during periods of low pollution (summer) and high pollution (winter). Assessments included symptom questionnaires, pulmonary function tests, bronchial provocation tests (BPT), serum total antioxidant status (TAS), and total oxidative status.
resultsIn the high pollution period, the NAR group exhibited significantly lower TAS levels compared to summer (1.51±0.15, 1.60±0.2,
conclusionSeasonal air pollution exerts phenotype-specific effects on oxidative stress and airway reactivity in rhinitis. AR patients exhibited increased bronchial hyperresponsiveness, whereas NAR individuals showed a marked decline in antioxidant capacity. These findings highlight the importance of phenotype-based monitoring and management during periods of high environmental exposure.
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