ReviewAllergy, asthma & immunology research2026
Skin Barrier Dysfunction in Contact and Atopic Dermatitis: A Comparative Review.
Review in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
The epidermis, the outermost layer of the skin, consists of 5 distinct layers, with the stratum corneum (SC) serving as the primary barrier. Disruption of skin barrier leads to inflammatory skin conditions, including irritant contact dermatitis (ICD), allergic contact dermatitis (ACD), and atopic dermatitis (AD). ICD arises from direct damage to the SC by irritants, while ACD is mediated by a type IV hypersensitivity. AD is characterized by chronic inflammation and genetic defects that compromise barrier integrity. Accordingly, strategies aimed at barrier restoration, such as the use of ceramide-based moisturizers, are key therapeutic approaches. Recent guidelines emphasize the importance of barrier-enhancing interventions, yet compliance remains a challenge in occupational settings. This review explores the implications of skin barrier dysfunction in contact dermatitis and AD, highlighting emerging therapeutic strategies aimed at restoring barrier function and reducing disease burden.
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