ReviewActa medica academica2026
Appendiceal Neuroendocrine Tumors in Children and Adolescents.
Review in Acta medica academica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo synthesize current evidence on the diagnosis, histopathological evaluation, clinical features, management, and follow-up of appendiceal neuroendocrine tumors (aNETs) in children and adolescents, and to outline key differences from their adult counterparts.
backgroundPediatric aNETs are rare gastrointestinal neoplasms that typically exhibit an indolent clinical course with minimal risk of recurrence or metastasis. Their biological and prognostic features differ from those in adults, limiting the applicability of adult-derived guidelines in children.
methodsA mini review of the current literature was conducted, focusing on epidemiology, clinical presentation, diagnostic workup, key pathological features, surgical management, and follow- up strategies for pediatric aNETs. DISCUSSION: Contemporary evidence supports a de-escalated, risk-adapted approach to management, with simple appendectomy being curative in most cases. Multidisciplinary Team (MDT) discussion remains critical for atypical or borderline cases requiring individualized decision-making. Differences from adult aNETs highlight the need for pediatric-specific clinical decision-making.
conclusionEarly recognition, accurate histopathologic evaluation, and tailored surgical management are essential to optimize outcomes for children and adolescents with aNETs.
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