ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Dynamic changes in gut microbiota from 1 to 12 months of age in preterm infants].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the dynamic development of gut microbiota in preterm infants during their first year after birth and to compare the microbiota profiles between preterm infants of different gestational ages.
methodsIn this prospective study, 81 preterm infants (including 37 early preterm and 44 moderate-to-late preterm infants) and 26 full-term infants were enrolled from Shenzhen Bao'an Women and Children's Hospital between January 2021 and September 2022. Fecal samples were collected at 1, 6, and 12 months of age. 16S rRNA sequencing was conducted, followed by comprehensive bioinformatics analysis.
resultsThe alpha diversity indices of the gut microbiota in preterm infants increased significantly from 1 to 12 months of age (
conclusionsThe gut microbiota of preterm infants becomes progressively more diverse during the first year of life. Preterm infants with lower gestational age harbor a higher relative abundance of potentially pathogenic genera in their early gut microbiota. However, the influence of gestational age on microbial composition diminishes over time.
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