ArticleBrain and behavior2026
Knockout of Low-Density Lipoprotein Receptor-Related Protein 1 From Astrocytes in Adult Mice Accelerates Long-Term Functional Recovery After Ischemic Stroke.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeIschemic stroke is a primary cause of death and disability worldwide; however, therapeutic opportunities are limited. Astrocytes, a major class of caretaker glia in the brain, can significantly alter outcomes after stroke through multiple pathways. Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional receptor that can modulate cellular signaling through its interaction with a diverse array of signaling mediators; however, its role in astrocyte function is not well elucidated. We tested whether LRP1 in astrocytes could alter outcomes in both the acute phase (24 h) and chronic phase (3-9 months) after middle cerebral artery occlusion in mice.
methodsAstrocyte-specific Lrp1 knockout mice were generated by crossing Cx30-CreER
findingsWe found that genetic knockout of Lrp1 in astrocytes worsened motor coordination in mice acutely after middle cerebral artery occlusion, but paradoxically improved long-term outcomes by 3 months after stroke. Notably, at 3 months post-stroke, loss of astrocyte LRP1 was associated with improved motor outcomes and reduced gliosis.
conclusionOur results suggest that loss of astrocyte LRP1 accelerates recovery after ischemic stroke.
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