Evidence map›Paper›PMID 41914203›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Gamma SARS-CoV-2 variant of concern infection repercussions on pregnancy outcomes: A translational cohort study.

Guilherme M Nobrega, Fabiana Granja, Mariene R Amorim, Luciana S Mofatto, Daniel A Toledo-Teixeira, Julia Forato, Priscilla P Barbosa, Jose Paulo S Guida, Adriana G Luz, Giuliane J Lajos and 18 more

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In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Guilherme M NobregaDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9406-4256
Fabiana GranjaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Mariene R AmorimLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Luciana S MofattoLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Daniel A Toledo-TeixeiraLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Julia ForatoLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Priscilla P BarbosaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Jose Paulo S GuidaDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Adriana G LuzDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Giuliane J LajosDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Carolina C Ribeiro-do-ValleDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Gisele A PedrosoDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Kamila C S KrywaczDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Angelica Z SchreiberDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Giuliana D MorenoDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rodrigo N AngeramiDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Maria Luiza MorettiDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rodolfo C PacagnellaDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Renato T SouzaDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Jose Guilherme CecattiDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rodrigo G StabeliOswaldo Cruz Foundation (Fiocruz-SP), Ribeirão Preto, São Paulo, Brazil.
Magnun N N SantosDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Fernando R SpilkiOne Health Laboratory, Feevale University, Novo Hamburgo, Rio Grande do Sul, Brazil.
Ester C SabinoTropical Medicine Institute, Medical School, University of São Paulo, São Paulo, São Paulo, Brazil.
Nuno R FariaDepartment of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo, São Paulo, Brazil.
William M de SouzaWorld Reference Center for Emerging Viruses and Arboviruses and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jose Luiz Proenca-ModenaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Maria Laura CostaDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8280-3234

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 141844/2019-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 305628/2020-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 382206/2020-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 408407/2021-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.356527/2019-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.513498/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.600190/2021-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.661921/2022-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.712761/2022-00Financiadora de Estudos e Projetos 01.20.0003.00Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/00194-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/14372-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04558-0Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 2266/20Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 2300/20Global Virus Network FellowshipMedical Research Council and FAPESP-Brazil-UK Center for (Arbo) virus Discovery, Diagnosis, Genomics, and Epidemiology partnership award FAPESP 2018/14389-0Medical Research Council and FAPESP-Brazil-UK Center for (Arbo) virus Discovery, Diagnosis, Genomics, and Epidemiology partnership award MR/S0195/1Wellcome TrustWellcome Trust and Royal Society Sir Henry Dale Fellowship 204311/Z/16/Z
6 · The paper itself

Abstract

objectiveThis study conduct viral genome sequencing among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pregnant and postpartum individuals, and investigates disease severity and maternal and perinatal outcomes considering variant of concern (VOC) and non-VOC groups.

methodsThe study was designed as a prospective cohort study of unvaccinated pregnant and postpartum women with SARS-CoV-2 infection diagnosed by quantitative reverse transcription polymerase chain reaction between May 2020 and April 2021 at a maternal referral center. Initially, 111 participants were identified, and 50 presented with conditions for genome sequencing and further analysis. The SARS-CoV-2 genome was subjected to next-generation sequencing in eligible cases. Sociodemographic characteristics, background, and clinical and obstetric outcomes were compared according to the SARS-CoV-2 genomic data (VOC vs. non-VOC).

resultsAmong the sequenced cases, 18 were classified as VOC, among which 14 were Gamma cases and four Alpha. Oxygen desaturation, hospitalization, intensive care unit admission, invasive ventilation, and maternal death were significantly higher in SARS-CoV-2 VOC-infected than in non-VOC-infected cases. All three cases of maternal death were classified as VOC, including two Gamma and one Alpha.

conclusionPregnant and postpartum people presented with an increased morbidity and mortality due to COVID-19 caused by SARS-CoV-2 VOC, especially Gamma. The increased risk of clinical severity in the unvaccinated obstetric population underscores the importance of addressing the repercussions of the SARS-CoV-2 genomic evolution.

Indexed as

COVID-19Pregnancy Complications, InfectiousPregnancy OutcomeSARS-CoV-2AdultCohort StudiesFemaleGenome, ViralHumansPostpartum PeriodPregnancyProspective StudiesSeverity of Illness IndexCOVID‐19maternal healthmorbiditypregnancySARS‐CoV‐2translational research

Identifiers

PMID41914203
PMCPMC13505251

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