Evidence map›Paper›PMID 41914145›Full record

ArticleCirculation. Heart failure2026

Single-Nuclei Transcriptomic Profiling of Human Myocardium in Long-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency.

Hanna J Tadros, Diwakar Turaga, Yi Zhao, Chang-Ru Tsai, Lalita Wadhwa, Debra L Kearney, Iki Adachi, Xiao Li, James F Martin

Abstract read
In one paragraph

Article in Circulation. Heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanna J TadrosDivision of Pediatric Cardiology (H.J.T.), Texas Children's Hospital, Houston.ORCID 0000-0002-2348-9262
Diwakar TuragaDivision of Critical Care Medicine (D.T.), Texas Children's Hospital, Houston.ORCID 0000-0003-2775-3320
Yi ZhaoThe Texas Heart Institute at Baylor College of Medicine, Houston, TX (Y.Z., X.L., J.F.M.).ORCID 0000-0003-0989-8825
Chang-Ru TsaiDepartment of Integrative Physiology (C.-R.T., J.F.M.), Baylor College of Medicine, Houston, TX.ORCID 0000-0001-5672-1235
Lalita WadhwaDepartment of Surgery (L.W., I.A.), Baylor College of Medicine, Houston, TX.ORCID 0000-0003-4506-7826
Debra L KearneyDepartment of Pathology (D.L.K.), Texas Children's Hospital, Houston.
Iki AdachiDivision of Congenital Heart Surgery (I.A.), Texas Children's Hospital, Houston.
Xiao LiDepartment of Molecular and Human Genetics (X.L.), Baylor College of Medicine, Houston, TX.ORCID 0000-0001-8527-4438
James F MartinDepartment of Integrative Physiology (C.-R.T., J.F.M.), Baylor College of Medicine, Houston, TX.ORCID 0000-0002-7842-9857

Funding

Pitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1M
Cytoskeletal Control of Yap in Heart RegenerationR01HL169511 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI James F Martin · 2023 to 2026
$2.7M
Reawakening cardiomyocyte proliferation from structural mediated quiescenceR01HL171574 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI James F Martin, Sean M Wu · 2024 to 2026
$1.9M
Hippo-YAP signaling in cardiac regenerative repairR01HL173242 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI James F Martin · 2025 to 2026
$1.4M
Senescent Cell States in Single Ventricle Disease with Heart FailureR01HL177644 · NHLBI · TEXAS HEART INSTITUTE · PI James F Martin · 2025 to 2026
$1.3M
Targeting Senescent Macrophages to Improve Heart Failure OutcomesR01HL179012 · NHLBI · TEXAS HEART INSTITUTE · PI LI, XIAO · 2025 to 2025
$1.3M
NHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL169511NHLBI NIH HHS R01 HL171574NHLBI NIH HHS R01 HL173242NHLBI NIH HHS R01 HL177644NHLBI NIH HHS R01 HL179012
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

3-hydroxyacyl-CoA dehydrogenase deficiencycardiomyopathiesfatty acidheart failuremyocardium

Identifiers

PMID41914145
PMCPMC13107969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.