Evidence map›Paper›PMID 41914049›Full record

ArticleBritish journal of haematology2026

In-depth analysis of osmotic gradient ektacytometry parameters across different genotypes in hereditary spherocytosis.

Jonathan R A de Wilde, Geoffrey Z L Kuppens, Maryse E Boesveld, Annelies J van Vuren, Wouter W van Solinge, Esmé Waanders, Eduard J van Beers, Minke A E Rab, Marije Bartels, Richard van Wijk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan R A de WildeRed Blood Cell Research Group, Central Diagnostic Laboratory-Research, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-6033-2945
Geoffrey Z L KuppensCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-6678-2071
Maryse E BoesveldRed Blood Cell Research Group, Central Diagnostic Laboratory-Research, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Annelies J van VurenDepartment of Internal Medicine, Ziekenhuisgroep Twente, Almelo, The Netherlands.ORCID https://orcid.org/0000-0002-4258-3836
Wouter W van SolingeRed Blood Cell Research Group, Central Diagnostic Laboratory-Research, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0003-2867-2581
Esmé WaandersDepartment of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-2466-953X
Eduard J van BeersCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-3934-7189
Minke A E RabRed Blood Cell Research Group, Central Diagnostic Laboratory-Research, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-8306-8726
Marije BartelsCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-9685-1755
Richard van WijkRed Blood Cell Research Group, Central Diagnostic Laboratory-Research, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-8236-8292

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary spherocytosis (HS) is a hereditary haemolytic anaemia, caused by pathogenic variants in genes encoding red blood cell membrane proteins. Osmotic gradient ektacytometry evaluates red cell deformability and hydration and is increasingly used in the diagnosis of HS. We retrospectively evaluated laboratory data from 233 HS patients focusing on osmotic gradient ektacytometry parameters, including two novel parameters, O

Indexed as

Erythrocyte DeformabilitySpherocytosis, HereditaryAdolescentAdultAnion Exchange Protein 1, ErythrocyteAnkyrinsChildChild, PreschoolFemaleGenotypeHumansInfantMaleMiddle AgedRetrospective StudiesSpectrinAnion Exchange Protein 1, ErythrocyteANK1 protein, humanAnkyrinsSLC4A1 protein, humanSpectrinSPTB protein, humanclassification of disease severitydiagnosticshereditary spherocytosisosmotic gradient ektacytometry

Identifiers

PMID41914049
PMCPMC13176518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.