Evidence map›Paper›PMID 41913941›Full record

ReviewImmunology and cell biology2026

Neuroinflammation as a result of non-neurotropic herpesvirus infection.

Christian Münz

Abstract readReview
In one paragraph

Review in Immunology and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. EBNA1Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Funding

HORIZON EUROPE Health 101137235Krebsliga Schweiz KFS-5896-08-2023-RSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030E_238141Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 3200-0-239903Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung CRSII_222718_10000065
6 · The paper itself

Abstract

The non-neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by which EBV might cause neuroinflammatory B-cell migration to the central nervous system (CNS), as observed during primary CNS lymphomas and MS. Furthermore, mechanisms of molecular mimicry and autoreactive B-cell expansion by EBV will also be summarized. Finally, approaches to target EBV-mediated neuroinflammation for therapeutic interventions in people with MS (pwMS) will be explored. The recently provided information on EBV's association with MS gives exciting insights into the initiation of this autoimmune disease. Successful therapeutic interventions on the basis of this knowledge might provide evidence that EBV contributes also to the clinical phase of this autoimmune disease.

Indexed as

Epstein-Barr Virus InfectionsHerpesviridae InfectionsHerpesvirus 4, HumanMultiple SclerosisNeuroinflammatory DiseasesAnimalsB-LymphocytesHumansMolecular Mimicryatypical memory B cells (ABCs)Epstein Barr virus (EBV)molecular mimicrymultiple sclerosis (MS)systemic lupus erythematosus (SLE)

Identifiers

PMID41913941
PMCPMC13155061

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.