ArticleCureus2026
First-Line Enfortumab Vedotin Plus Pembrolizumab in Platinum-Ineligible Urothelial Carcinoma: A Three-Case Series.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- First-line Enfortumab Vedotin Plus Pembrolizumab in Platinum-ineligible Advanced Urothelial Carcinoma.Cancer diagnosis & prognosisArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locally advanced or metastatic urothelial carcinoma (la/mUC) has a poor prognosis. In routine clinical practice, platinum-based chemotherapy has generally been used as first-line treatment. Enfortumab vedotin plus pembrolizumab (EVP) has recently been introduced as another first-line option; however, patients who are platinum-ineligible, such as those with severe renal dysfunction and/or poor performance status, are often underrepresented in clinical studies, and the optimal systemic therapy for this group remains uncertain. Herein, we report three platinum-ineligible patients with la/mUC who received standard-dose EVP as first-line therapy. Platinum ineligibility was defined as creatinine clearance (CrCl) < 30 mL/min and/or Eastern Cooperative Oncology Group performance status (ECOG PS) ≥ 3. In Case 1 (hemodialysis; ECOG PS 1), EVP resulted in improvement of bone metastases and durable disease control, with manageable adverse events (AEs), including grade 2 skin toxicity, dysgeusia, hypothyroidism, and transient peripheral sensory neuropathy that resolved after temporary treatment interruption. In Case 2 (CrCl 23.1 mL/min; ECOG PS 2), EVP induced a partial response in the bladder and nodal lesions; however, treatment was complicated by early-onset grade 4 immune-related nephritis requiring high-dose corticosteroids. Best supportive care was adopted at progression. In Case 3 (ECOG PS 3), rapidly progressive renal pelvic la/mUC showed early disease progression with spinal cord compression despite EVP, leading to the patient being transitioned to best supportive care. Across all three cases, no life-threatening toxicity was clearly attributable to enfortumab vedotin. These observations suggest that standard-dose EVP may be a feasible first-line option for carefully selected platinum-ineligible patients, when administered with close monitoring, flexible dose adjustment, and prompt management of immune-related and other AEs.
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