ArticleClinical, cosmetic and investigational dermatology2026
Causal Association Between Ankylosing Spondylitis and Hidradenitis Suppurativa: A Twosample Bidirectional Mendelian Randomization Study.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Ankylosing spondylitis (AS) and hidradenitis suppurativa (HS) represent two chronic inflammatory diseases that share similar underlying immunological characteristics. Observational studies suggest a potential association, but the causal relationship remains underexplored. Objective: To evaluate bidirectional causal links between AS and HS using Mendelian randomization (MR). Methods: We implemented two-sample bidirectional MR analyses, utilizing summary statistics obtained from genome-wide association study (GWAS) datasets. Genetic instruments for AS (ncase=9069, ncontrol=1550) and HS (ncases=409, ncontrols=211,139) were selected under stringent criteria (p<5e-5 LD clumping: r Results: Genetically predicted AS significantly increased HS risk (IVW OR=3.49, 95% CI=1.43-8.52, P=0.006), with no evidence of reverse causation (HS→AS: OR=1.00, 95% CI=0.9998-1.00, P=0.816). To validate the stability of our estimates, sensitivity analyses were performed. The MR-Egger intercept and Cochran's Q test yielded nonsignificant P values (both P>0.05), supporting the robustness of our findings. Conclusion: This investigation provides genetic evidence indicating a causal relationship between ankylosing spondylitis and an increased risk of hidradenitis suppurativa, underscoring a shared etiological pathway, likely involving the IL-17/IL-23 axis. No significant causal effect was observed from HS to AS within the limitations of the current data.
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