ReviewJournal of inflammation research2026
The Crosstalk Between Efferocytosis and Macrophage Polarization in Diabetic Wounds: A Comprehensive Review.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Natural Polysaccharide-Based Biomaterials for Skin Wound Healing: Immunomodulatory Mechanisms and Macrophage M2 Polarization.Gels (Basel, Switzerland) · 2026Review
- Pachymic Acid Accelerated Diabetic Ulcer Healing by Enhancing Macrophage Efferocytosis via the MEK/ERK/TGFβ1 Signaling Axis.Journal of diabetes research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic refractory cutaneous wounds are major complications of diabetes. A hallmark of this pathology is persistent inflammation, driven in part by the accumulation of apoptotic cells (ACs) due to impaired clearance. Efferocytosis, as the primary process for removing ACs, was disordered when triggered by the diabetic microenvironment, further leading to impaired macrophage polarization and consequently delaying wound healing. This review also focuses on the abnormal crosstalk between efferocytosis and macrophage polarization and its modulated signaling pathways governing this axis, and reviewing potential novel therapeutic strategies targeting the restoration of clearing ACs. This review may offer new insights and directions for overcoming current treatment drawbacks in diabetic wound healing.
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Registered trials
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