ArticleJournal of inflammation research2026
Yin-Hua Li-Shi Formula Exerts Anti-Atopic Dermatitis Effects Through Luteolin Targeting AKT/MAPK-IL-6/IL-17 Axis.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Yin-Hua Li-Shi Formula (YHLS), a medically authorized traditional Chinese medicine (TCM) formulation for atopic dermatitis (AD), has a 30-year clinical application history in China, yet has not had its precise therapeutic mechanisms fully elucidated to date. Methods: Chemical profiling of YHLS was conducted using high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Network pharmacology predicted YHLS's active ingredients, therapeutic targets, and anti-atopic dermatitis (AD) pathways, with molecular docking validating component-target binding affinity. By intersecting network pharmacology/molecular docking results with mass spectrometry profiles, the key bioactive component was identified. For in vivo validation, an AD-like model was generated via topical MC903 application in C57BL/6 mice. Dermatitis severity, ear thickness, H&E staining, ELISA, RT-qPCR, and Western blot were performed to assess YHLS's efficacy and underlying mechanisms. Results: Luteolin, the major bioactive component of YHLS targeting AD, was identified by intersecting UPLC-MS/MS metabolite profiles with network pharmacology and molecular docking results. Network pharmacology revealed 102 common targets between YHLS and AD, with PPI/KEGG analyses confirming MAPK1 and AKT1 as core inflammatory targets. Molecular docking assays demonstrated that luteolin binds tightly to MAPK1 (-8.2 kcal/mol) and AKT1 (-9.7 kcal/mol). In MC903-induced AD-like mice, YHLS alleviated symptoms dose-dependently (reduced severity scores, ear thickness, hyperkeratosis, and inflammatory infiltration; all Conclusion: Luteolin is the major bioactive component of Yin-Hua Li-Shi Formula (YHLS) that mediates its anti-atopic dermatitis effects by specifically targeting the AKT/MAPK-IL-6/IL-17 axis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.