Trial reportDrug design, development and therapy2026
Effect of Intraoperative Low-Dose Esketamine on Postoperative High-Sensitivity Troponin T in Elderly Patients Undergoing Ivor Lewis Esophagectomy.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interpreting Reduced Postoperative hs-cTnT After Intraoperative Esketamine: Methodological Considerations [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Ivor Lewis esophagectomy impacts circulatory and cardiac function significantly, often leading to elevated postoperative troponin levels. This study aimed to investigate the effect of low-dose esketamine on postoperative levels of the myocardial injury marker high-sensitivity cardiac troponin T in elderly patients undergoing this procedure. Patients and Methods: 70 elderly patients scheduled for elective Ivor Lewis esophagectomy were randomly assigned using a random number table to the Control group (Group C, n=35) or the Esketamine group (Group K, n=35). In Group K, in addition to conventional anesthetic drugs, intravenous esketamine 0.25 mg/kg was administered during anesthesia induction, followed by continuous intraoperative infusion at 0.125 mg/kg/h as an adjunct to balanced anesthesia. The Control group received conventional anesthesia induction and maintenance. The primary outcome was hs-cTnT concentration at 24 h postoperatively. Results: In Group K, hs-cTnT concentrations were significantly lower than in the control group at 24h (12.1 ± 3.5 vs 18.7 ± 4.7, P < 0.0001) postoperatively, as well as at 6-12h and 48h postoperatively. Although the incidence of myocardial injury within 2 days postoperatively (11.4% vs 22.9%, P = 0.205) and perioperative severe arrhythmias (2.9% vs 11.4%, P = 0.164) was lower in Group K than in Group C, the differences were not statistically significant. Compared to the control group, Group K indicated more stable hemodynamics. Among postoperative complications, the incidence of dreaming was higher in Group K, with no significant differences in other complications. For postoperative pain, Group K had lower Numerical Rating Scale (NRS) scores at PACU discharge and on postoperative day 1 to day 3. The PACU stay was shorter in Group K. Conclusion: Intraoperative low-dose esketamine effectively reduced hs-cTnT concentrations within 2 days postoperatively in elderly patients undergoing Ivor Lewis esophagectomy, demonstrating a potential beneficial effect in preventing myocardial injury and cardiovascular adverse events.
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