Evidence map›Paper›PMID 41913570›Full record

ArticleAnnals of geriatric medicine and research2026

A Case Series on Longitudinal Hypothalamic Morphology in Mild Cognitive Impairment.

Jeffrey Cayaban Pagaduan, Melvin Barrientos Marzan, Xiaoling Wang, Benjamin Billot

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In one paragraph

Article in Annals of geriatric medicine and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffrey Cayaban PagaduanMelbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia. jcpagaduan@gmail.com.
Melvin Barrientos MarzanDepartment of Obstetrics, Gynaecology & Newborn Health, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
Xiaoling WangGeorgia Prevention Institute, Augusta University, Augusta, GA, USA.
Benjamin BillotComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the longitudinal hypothalamic morphology in the progression of mild cognitive impairment (MCI). We used multivariable linear modelling to differentiate the structural volumetric change in the hypothalamic nuclei in nine females who developed MCI after 5 years and 61 healthy controls. We found significantly decreased left anterior-inferior (p<0.01), left anterior-superior (p<0.05), and left posterior (p<0.01) hypothalamic regions among females with MCI compared to healthy controls. There was also a significant asymmetry at the anterior-superior hypothalamus (p<0.05) in MCI females than in healthy controls. Thus, the degradation of the specific left hypothalamic subregions and leftward lateralization over time highlight the impact of early- stage MCI on the morphology of hypothalamus.

Indexed as

Cognitive DysfunctionHypothalamusAgedAged, 80 and overCase-Control StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingAgingBrainHypothalamusMagnetic resonance imagingNeurodegenerative diseases

Identifiers

PMID41913570
PMCPMC13327814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.