Evidence map›Paper›PMID 41913335›Full record

ArticlePharmacoepidemiology and drug safety2026

Oral Anticoagulant Use Among Older Adults in Long-Term Care Facilities: Trends Over Time and Impact of High-Risk Comorbidities.

S L Harrison, M C Inacio, T Air, C Lang, J K Sluggett, C Whitehead, G E Caughey

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Article in Pharmacoepidemiology and drug safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

S L HarrisonRegistry of Senior Australians Research Centre, Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia.ORCID https://orcid.org/0000-0002-8846-0946
M C InacioRegistry of Senior Australians Research Centre, Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia.
T AirRegistry of Senior Australians Research Centre, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
C LangRegistry of Senior Australians Research Centre, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
J K SluggettRegistry of Senior Australians Research Centre, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
C WhiteheadCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
G E CaugheyRegistry of Senior Australians Research Centre, Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia.

Funding

Australian Government Medical Research Future Fund PHRDI000009Bolton ClarkeCaring Futures InstituteCollege of Nursing and Health Science at Flinders UniversityECH Inc.National Health and Medical Research Council GNT119378National Health and Medical Research Council GNT2016277National Health and Medical Research Council GNT2026400SilverchainSouth Australian Health and Medical Research Institute
6 · The paper itself

Abstract

purposeTo examine oral anticoagulant (OAC) use in older adults residing in long-term care facilities (LTCFs) since direct OACs (DOACs) were introduced, including trends over time and in people with high-risk comorbidities (prior gastrointestinal bleed and dementia).

methodsA repeated cross-sectional study using the Registry of Senior Australians National Historical Cohort was conducted and included individuals aged ≥ 65 years residing in LTCFs in Australia between 2013 and 2019. Yearly age- and sex-adjusted prevalence of OACs and 95% confidence intervals (CIs) were estimated using generalised estimating equation (GEE) Poisson models and adjusted prevalence ratios (aPRs) were calculated to estimate trends.

resultsIn 500 883 individuals, the prevalence of OAC use increased from 12.2% (95% CI 12.1-12.4) in 2013 to 16.5% (95% CI 16.4-16.7) in 2019 [aPR 1.05 (95% CI 1.05-1.05)]. This was driven by an increase in the use of DOACs, from 2.24% (95% CI 2.19-2.29) to 12.5% (95% CI 12.3-12.6) [aPR 1.25 (95% CI 1.25-1.26)]. Increases in OAC use were also observed in people with prior gastrointestinal bleed, from 12.9% (95% CI 11.8-13.9) to 17.1% (95% CI 16.2-17.9) [aPR 1.05 (95% CI 1.03-1.06)]. The use of OACs increased over the study period for people living with dementia from 9.93% to 12.8% [aPR 1.04 (95% CI 1.04-1.05)], and for people without dementia from 15.7% to 21.7% [aPR 1.06 (95% CI 1.06-1.06)].

conclusionsThis population-based study showed increasing use of OACs among residents of LTCFs, including in higher-risk comorbidity groups, indicating growing confidence in the use of DOACs in these groups.

Indexed as

AnticoagulantsLong-Term CareAdministration, OralAgedAged, 80 and overAustraliaComorbidityCross-Sectional StudiesDementiaFemaleGastrointestinal HemorrhageHumansMaleNursing Home ResidentsPrevalenceRegistriesAnticoagulantsanticoagulantslong‐term care facilitiespopulation‐based study

Identifiers

PMID41913335
PMCPMC13036282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.