Evidence map›Paper›PMID 41913331›Full record

ArticleJournal of magnetic resonance imaging : JMRI2026

Association Between the Systemic Immune-Inflammation Index and Aneurysmal Wall Enhancement on High-Resolution Magnetic Resonance Vessel Wall Imaging in Unruptured Intracranial Aneurysms.

Jiwan Huang, Runze Ge, Caihong Li, Yuxin Li, Zhuohua Wen, Chi Huang, Anqi Xu, Mengshi Huang, Jiancheng Lin, Hao Yuan and 16 more

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Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

26 authors.

Jiwan HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Runze GeNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Caihong LiDepartment of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Yuxin LiDepartment of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Zhuohua WenNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Chi HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Anqi XuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mengshi HuangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jiancheng LinNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hao YuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hongyu ShiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Can LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Lele DaiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wenxin ChenNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xiru ZhangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yi TuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Canzhao LiuEngineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Department of Cardiology, Laboratory of Heart Center, Translational Medicine Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shuyin LiangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yiming BiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wenchao LiuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shixing SuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xin ZhangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xifeng LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
ZhiBo WenDepartment of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Chuanzhi DuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2025-8637
Xin FengNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Speciality, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Funding

National Natural Science Foundation of China 82201427National Natural Science Foundation of China U21A6005the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJ2022100102the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJQ2022100104the Foundation of National Health Commission Capacity Building and Continuing Education Center GWJJQ2023100101
6 · The paper itself

Abstract

backgroundInflammation is a critical driver of intracranial aneurysm (IA) instability. The systemic immune-inflammation index (SII), a novel composite inflammatory biomarker, may reflect the local mural changes observed on vessel wall imaging (VWI). PURPOSE/HYPOTHESIS: To investigate the association between the SII and aneurysmal wall enhancement (AWE) on high-resolution vessel wall imaging (HRVWI), and to evaluate SII as a potential biomarker for aneurysm instability. STUDY TYPE: Prospective cross-sectional study. POPULATION: Four hundred and eighteen intracranial aneurysms in 311 patients (65.3% female, median age 58.0 years) underwent HRVWI. A sub-cohort of 67 patients with 84 aneurysms was included for longitudinal analysis of aneurysm growth (median follow-up 7.0 months). FIELD STRENGTH/SEQUENCE: Field strength/sequence: A 3.0T MR scanner; 3D time-of-flight magnetic resonance angiography (TOF-MRA); 3D black-blood T1-weighted volumetric turbo spin echo acquisition (T1-VISTA); and post-contrast vessel wall imaging using a 3D fast field echo sequence. ASSESSMENT: AWE defined as aneurysm-to-pituitary stalk contrast ratio (CR STATISTICAL TESTS: Multivariable logistic regression and propensity score matching evaluated the association between SII and AWE. Longitudinal analysis was performed using Firth's logistic regression. Subgroup analyses were stratified by clinical and aneurysmal characteristics. p < 0.05 was considered significant.

resultsAWE was present in 142/418 (34.0%) aneurysms. In multivariable analysis, elevated SII was independently associated with AWE (odds ratio [OR] = 1.93). This association remained significant after PSM (median SII: 0.60 in AWE group vs. 0.42 in non-AWE group). SII was also independently associated with aneurysm growth in the longitudinal sub-cohort (OR = 20.519). Subgroup analysis showed a significant interaction with aneurysm location, with the strongest association in the internal carotid artery (OR = 3.55; 95% CI: 1.63-7.71). DATA

conclusionElevated SII is independently associated with the presence of AWE and aneurysm growth. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.

Indexed as

InflammationIntracranial AneurysmMagnetic Resonance AngiographyAgedBiomarkersCross-Sectional StudiesFemaleHumansImaging, Three-DimensionalMaleMiddle AgedProspective StudiesBiomarkersaneurysm wall enhancementintracranial aneurysmsystemic immune‐inflammation indexvessel wall imaging

Identifiers

PMID41913331
PMCPMC13356442

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