Evidence map›Paper›PMID 41913316›Full record

Observational studyThe journal of obstetrics and gynaecology research2026

Psychosocial Burden of Women With Cervical Intraepithelial Neoplasia in Japan: Results of A Web-Based Survey.

Kayo Sato, Nobuyuki Oshima, Mamiko Onuki, Koji Matsumoto, Kotoba Okuyama

Abstract readObservational Study
In one paragraph

Observational study in The journal of obstetrics and gynaecology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Kayo SatoMSD K.K, Tokyo, Japan.
Nobuyuki OshimaMSD K.K, Tokyo, Japan.
Mamiko OnukiDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Koji MatsumotoDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-6184-618X
Kotoba OkuyamaMSD K.K, Tokyo, Japan.

Funding

MSD K.K.
6 · The paper itself

Abstract

aimHuman papillomavirus (HPV) infection carries a high risk of developing cervical intraepithelial neoplasia (CIN) and cancer in women. For women with CIN, follow-up examinations and treatment are necessary and pose a psychosocial burden. This study investigated the psychosocial burden among women with CIN in Japan.

methodsThis observational, cross-sectional, online survey enrolled women aged 20-49 years in Japan who used a mobile health app (Kencom) linked to an employment-based health insurance association database. Participants completed a screening questionnaire on cervical screening history and CIN status. Eligible women then completed the HPV Impact Profile (HIP) to assess their psychosocial burden. CIN status was confirmed using diagnostic codes recorded in the Kencom database.

resultsA total of 404 women were eligible for the study, comprising 121 with confirmed CIN and 283 without CIN. The baseline characteristics were similar, although women with CIN were slightly younger (39.8 vs. 41.5 years) and less likely to be married (55.4% vs. 70.0%). Women with CIN had significantly higher total HIP scores, indicating greater burden than those without CIN (42.2 vs. 24.5; p < 0.001). The burden was evident in women with CIN grade 1 (p < 0.001) and more pronounced in younger women (trend for age groups; p < 0.001).

conclusionsThis study is the first to report a significant psychosocial burden of CIN in Japan, irrespective of CIN severity, with a greater impact in younger women. This psychosocial burden can be alleviated by HPV vaccination with evidence of preventing CIN.

Indexed as

Cost of IllnessPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultCross-Sectional StudiesFemaleHumansInternetJapanMiddle AgedSurveys and QuestionnairesYoung Adultcervical lesionshuman papillomavirusJapanonline surveypsychosocial burden

Identifiers

PMID41913316
PMCPMC13035917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.