Evidence map›Paper›PMID 41913271›Full record

ArticleJournal of nanobiotechnology2026

Zinc-coordination-driven mitochondrial nanodisruptors to ablate cancer stemness for potentiating immunotherapy in colorectal malignancies.

Yun Long, Wenting Cheng, Hailong Tian, Canhua Huang, Zhiqi Zhang, Yongfeng Jia, Shaojiang Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun Long *Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing, 404120, China.
Wenting Cheng *Department of Biotherapy, Institute of Oxidative Stress Medicine, Cancer Center, State Key Laboratory of Biotherapy, West China, School of Basic Medical Sciences and Forensic Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Hailong TianDepartment of Biotherapy, Institute of Oxidative Stress Medicine, Cancer Center, State Key Laboratory of Biotherapy, West China, School of Basic Medical Sciences and Forensic Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Canhua HuangDepartment of Biotherapy, Institute of Oxidative Stress Medicine, Cancer Center, State Key Laboratory of Biotherapy, West China, School of Basic Medical Sciences and Forensic Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Zhiqi ZhangDepartment of General Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, The People's Republic of China. zzq72@163.com.
Yongfeng JiaDepartment of Pathology, Basic Medical Sciences College, Inner Mongolia Medical University, Hohhot, China. yfjia0471@163.com.
Shaojiang ZhengThe Hainan Branch of National Clinical Research Center for Cancer, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, Hainan Cancer Medical Center of The First Affiliated Hospital, Hainan Medical University, Haikou, 570102, China. zshaojiang@muhn.edu.cn.

Funding

National Key R&D Program of China 2023YFC3402100National Natural Science Foundation of China 82130082, 82341004
6 · The paper itself

Abstract

Cancer stemness, sustained by mitochondrial metabolic plasticity, drives immunotherapy resistance in colorectal cancer (CRC). We reengineer zeolitic imidazolate framework-8 (ZIF-8), a zinc-coordination-driven metal-organic framework, from inert nanocarrier to a multifunctional mitochondrial synchronizer that disrupts stemness through tripartite bioenergetic targeting. A hyaluronic acid (HA)-modified nanoarchitecture (HA/ZGA) co-delivers glucose oxidase (GOx) and 5-aminolevulinic acid (5-ALA), leveraging ZIF-8's intrinsic Zn

Indexed as

Colorectal NeoplasmsImmunotherapyMitochondriaNeoplastic Stem CellsZincAnimalsCell Line, TumorHumansHyaluronic AcidImidazolesMetabolic ReprogrammingMetal-Organic FrameworksMiceHyaluronic AcidImidazolesMetal-Organic FrameworksZIF-8 metal-organic frameworkZincCell stemnessChemo-immunotherapyColorectal cancerEnergy deprivationZeolitic imidazolate nano-frameworks

Identifiers

PMID41913271
PMCPMC13200431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.