ArticleCell & bioscience2026
Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.
Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe testis exhibits the highest tissue-specific gene expression of all organs, including both coding and non-coding genes. Our previous study reported that Teshl, a testis-specific long noncoding RNA, associates with heat shock factor 2 (HSF2), a transcription factor, to regulate Y chromosome gene expression and sperm fertility.
resultsWe conducted an in-depth analysis of the function and molecular mechanisms of Teshl using Teshl-knockout (KO) mice. Remarkably, the absence of Teshl caused abnormal acrosome biogenesis during spermiogenesis, resulting in malformed and disorganized acrosomes and abnormal sperm head morphology. Teshl-KO sperm also exhibited altered acrosome reaction and reduced motility. A thorough examination of all available relevant datasets identified three Teshl-related proteins associated with acrosome structure and function: actin related protein T1 (ACTRT1), acrosin binding protein (ACRBP) and dickkopf-like acrosomal protein 1 (DKKL1). Our findings suggest that these proteins are directly or indirectly regulated by Teshl-HSF2 through transcriptional or protein-interaction mechanisms.
conclusionsThe present findings significantly expand our understanding of the important roles of Teshl, a pioneering testis-specific lncRNA, by elucidating its acrosomal function and mechanism in male reproduction.
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