Evidence map›Paper›PMID 41913188›Full record

ArticleAIDS research and therapy2026

Brief communication: observations of falsely reactive antigen/antibody HIV screening results in an emergency department setting.

Heather Hare, Emily Holbrook, Megan Sarmento, Rebecca Haber, Heather Henderson, Bernice McCoy, Samantha Reale, Angela Lauster, Jason Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heather HareFlorida State University College of Medicine, Tallahassee, FL, 32304, USA. hfh23@med.fsu.edu.
Emily HolbrookDepartment of Emergency Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33606, USA.
Megan SarmentoDepartment of Anthropology, University of South Florida, Tampa, FL, 33620, USA.
Rebecca HaberLake Eerie College of Osteopathic Medicine, Bradenton, FL, 34211, USA.
Heather HendersonDepartment of Emergency Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33606, USA.
Bernice McCoyDepartment of Emergency Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33606, USA.
Samantha RealeDepartment of Anthropology, University of South Florida, Tampa, FL, 33620, USA.
Angela LausterLaboratory Sciences, Tampa General Hospital, Tampa, FL, 33606, USA.
Jason WilsonDepartment of Emergency Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33606, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

False-positive HIV antigen/antibody screening disrupts medical care and has psychological implications for misdiagnosed patients. From 2018 to 2023, our emergency-department screened 102,369 patients for HIV. Among 698 reactive antigen/antibody screens, 582 (83.4%) were confirmed true positives and 116 (16.6%) were false-positive, defined as a reactive antigen/antibody test with an undetectable viral load. Among a series of 13 patients with false-positive results, we evaluated clinical characteristics and conducted repeat testing. False reactivity resolved in 10 (77%) cases while 3 (23%) cases were persistently discordant. False positivity was seen during immune activation states including acute non-HIV infection, autoimmune disease, hematologic conditions, and liver disease.

Indexed as

Emergency Service, HospitalHIV AntibodiesHIV AntigensHIV InfectionsMass ScreeningAdultFalse Positive ReactionsFemaleHumansMaleMiddle AgedViral LoadHIV AntibodiesHIV AntigensDiagnostic accuracyEmergency department screeningFalse positiveHIV serologyHuman immunodeficiency virusPublic health

Identifiers

PMID41913188
PMCPMC13047761

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Registered trials

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