Evidence map›Paper›PMID 41913064›Full record

ArticleThoracic cancer2026

Prediction of Histological Subtype Based on Segmental Localization of Malignant Pulmonary Nodule in the Upper Lobe of the Lung.

Aysegul Gencer, Ersan Atahan, Bilun Gemicioglu, Sermin Borekci, Buket Caliskaner Ozturk

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Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Aysegul GencerIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-8365-6210
Ersan AtahanIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-2993-243X
Bilun GemiciogluIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-5953-4881
Sermin BorekciIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-0089-1312
Buket Caliskaner OzturkIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-5514-1108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have shown that malignant pulmonary nodules frequently occur in the upper lobes of the lung. However, there is no data on their distribution according to segments. The aim of this study is to predict the histological subtype of lung cancer based on the segment localization of malignant pulmonary nodules located in the upper lobe of the lung.

methodsBetween March 1, 2018, and November 1, 2024, 2402 patients who applied to the pulmonary diseases outpatient clinic and were scheduled for further investigation after thoracic CT scans revealed pulmonary nodules measuring 8 mm or larger were screened. The demographic characteristics, pulmonary nodule size, and histological subtypes of 154 patients diagnosed with non-small cell lung cancer (NSCLC) in further investigations were compared according to the upper lobe segments of the lung: apicoposterior and anterior.

resultsAdenocarcinoma percentage was significantly higher in the apicoposterior group, while squamous cell carcinoma percentage was significantly higher in the anterior group (p = 0.010).

conclusionsNSCLC localized in the apicoposterior segment of the upper lobes of the lung tends to be adenocarcinoma, while those localized in the anterior segment tend to be squamous cell carcinoma. Tumor size less than 3 cm with apicoposterior localization is independently associated with the adenocarcinoma histological subtype.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsSolitary Pulmonary NoduleAgedFemaleHumansMaleMiddle AgedPrognosisTomography, X-Ray Computedlung cancerlung cancer histological subtypesmalignant pulmonary nodulemalign nodule segmenter location

Identifiers

PMID41913064
PMCPMC13140464

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