Evidence map›Paper›PMID 41913059›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology.

Teresa Macheda, Margaret R Hawkins, Carrie E Johnson, Madison G Lapid, Haleigh R Whitlock, Savannah M Shepard, MaKayla F Cox, Kelly N Roberts, Leke Bytyqi, Heather M Hash and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Teresa MachedaDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Margaret R HawkinsDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Carrie E JohnsonSanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Madison G LapidDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Haleigh R WhitlockDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Savannah M ShepardDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
MaKayla F CoxDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Kelly N RobertsDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Leke BytyqiDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Heather M HashDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Omar A Abou El-EzzDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Mohammed Abou El-EzzDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Katherina KohlerSanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Sridhar SunderamDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA.
Bruce F O'HaraDepartment of Biology, University of Kentucky, Lexington, Kentucky, USA.
Linda J Van EldikDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Michael P MurphySanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Marilyn J DuncanDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Adam D BachstetterDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.

Funding

Sleep Fragmentation and Alzheimer’s DiseaseR01AG068215 · NIA · UNIVERSITY OF KENTUCKY · PI BACHSTETTER, ADAM D, DUNCAN, MARILYN J. · 2020 to 2024
$3.8M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG078110 · NIA · UNIVERSITY OF KENTUCKY · PI Michael Paul Murphy, LINDA J VAN ELDIK · 2022 to 2026
$2.3M
NIA NIH HHS AG068215NIA NIH HHS R01 AG068215NIA NIH HHS T32 AG078110
6 · The paper itself

Abstract

introductionSleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear.

methodsWe longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPP

resultsOnly females exhibited midlife reductions in light-phase sleep, increased rhythm fragmentation, and reduced rhythm stability, coinciding with selective reversal learning deficits, effects independent of amyloid or cytokine burden. MW151 increased light-phase sleep and reduced cortical TNF-α without altering amyloid beta (Aβ) accumulation. DISCUSSION: HAPP

Indexed as

Alzheimer DiseaseCircadian RhythmCytokinesNeurogliaSleepSleep Wake DisordersAmyloid beta-PeptidesAnimalsDisease Models, AnimalFemaleGene Knock-In TechniquesMaleMiceMice, TransgenicAmyloid beta-PeptidesCytokinesAlzheimer's diseaseamyloid betacircadian rhythmscytokinesgliaknock‐in mouse modelMW151nesting behaviorneuroinflammationradial arm water mazesleep

Identifiers

PMID41913059
PMCPMC13140929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.