ReviewMolecular neurobiology2026
Cocaine Use Disorder: Neuropathology and Exploratory Treatments.
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleCocaine use disorder (CUD) is a clinically recognized condition characterized by compulsive drug-seeking behavior and neurobiological dysfunction. It results from complex interactions between neurotransmitter imbalances and neuroinflammatory processes. Given the growing understanding of its immunopathological effects, it is crucial to investigate the diverse mechanisms of CUD and assess new therapeutic approaches that target both neurochemical and inflammatory pathways.
objectivesThe main aim of this review is to gather information on the psychopharmacological mechanisms, neuroinflammatory features, and impact of cocaine hydrochloride on neurotransmitters, especially monoamines involved in CUD.
methodsAs the Food and Drug Administration has not approved any drugs for the treatment of CUD, we reviewed novel therapeutic agents and emerging treatment strategies for CUD from preclinical studies. We analyzed the current literature on CUD, focusing on its pathophysiology, neuroinflammation, and treatment. Relevant studies were sourced from PubMed, NCBI, AccessMedicine, and Clinical Key databases.
resultsPreclinical findings have suggested potentially promising treatments for CUD, including L-DOPA, M. pruriens, monoamine precursors, TA-CD (cocaine vaccine), and immunotherapy. In addition, these treatment modalities have had some success in subjects given their effects on targeting neuroinflammation.
conclusionsTargeting neuroinflammation with drugs and other modalities with specific therapeutic approaches may hold promise for treating patients with CUD. However, further research is needed as no FDA-approved treatment is yet available. These novel approaches may help reduce incidence rates within the CUD patient population and should be investigated further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.